Phydbac "Gene Function Predictor": a gene annotation tool based on genomic context analysis.
Phydbac "Gene Function Predictor": a gene annotation tool based on genomic context analysis.
复制标题
Phydbac“基因函数预测指标”：基于基因组上下文分析的基因注释工具。
DOI：
10.1186/1471-2105-6-247
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发表时间：
2005-10-12
影响因子：
3
通讯作者：
Claverie, JM
中科院分区：
文献类型：
--
作者：
Enault, F;Suhre, K;Claverie, JM
大量完全测序的基因组使基因组上下文分析能够预测原核蛋白之间可靠的功能关联。主要的方法依赖于这样一个事实，即编码物理上相互作用的伙伴或共享代谢途径成员的基因往往与基因组接近，以相关的方式进化，并在另一个生物体中融合为单一序列。新的“基因功能预测器”与网络服务器Phydbac相连，提出了大肠杆菌K-12蛋白之间的推定关联，这些蛋白质来自这些方法的组合。我们表明，通过该工具建立的关联比在其他已建立的数据库中发现的关联更准确。预测分配到氧化石墨烯类别，基于预先存在的功能注释的相关蛋白也可用。这个新数据库目前拥有9379个配对链接，预期成功率至少为80%，从这些链接中得出的6466个GO术语功能预测的准确率高于70%。“基因功能预测器”是一个自动工具，旨在帮助生物学家提供假设的功能预测基因组背景的特征。“基因功能预测器”可在。
The large amount of completely sequenced genomes allows genomic context analysis to predict reliable functional associations between prokaryotic proteins. Major methods rely on the fact that genes encoding physically interacting partners or members of shared metabolic pathways tend to be proximate on the genome, to evolve in a correlated manner and to be fused as a single sequence in another organism. The new "Gene Function Predictor", linked to the web server Phydbac proposes putative associations between Escherichia coli K-12 proteins derived from a combination of these methods. We show that associations made by this tool are more accurate than linkages found in the other established databases. Predicted assignments to GO categories, based on pre-existing functional annotations of associated proteins are also available. This new database currently holds 9,379 pairwise links at an expected success rate of at least 80%, the 6,466 functional predictions to GO terms derived from these links having a level of accuracy higher than 70%. The "Gene Function Predictor" is an automatic tool that aims to help biologists by providing them hypothetical functional predictions out of genomic context characteristics. The "Gene Function predictor" is available at .
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