Long Noncoding RNAs in the Pathogenesis of Barrett's Esophagus and Esophageal Carcinoma.
Long Noncoding RNAs in the Pathogenesis of Barrett's Esophagus and Esophageal Carcinoma.
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DOI：
10.1053/j.gastro.2017.04.046
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发表时间：
2017-07
期刊：
影响因子：
29.4
通讯作者：
Meltzer SJ
中科院分区：
文献类型：
--
作者：
Abraham JM;Meltzer SJ
多年来，只有一小部分人类基因组被认为调节细胞功能和发育。这个蛋白质编码部分只占30亿人类DNA碱基对的1%到2%，其余的序列被归类为垃圾DNA。随后的研究表明，大部分基因组被转录成一系列非编码RNA，大小从microRNA（20-23个核苷酸）到长非编码RNA（lncRNA，超过200个核苷酸）不等。这些非编码RNA类已被证明使用不同的分子机制来控制基因表达和器官系统发育。正如预期的那样，这个大的控制系统的改变可以有助于疾病的发病机制和致癌作用。本文综述了非编码RNA-lncRNA在Barrett食管和食管癌发生发展中的作用。
For many years, only a small fraction of the human genome was believed to regulate cell function and development. This protein-coding portion composed only 1% to 2% of 3 billion human DNA base pairs— the remaining sequence was classified as junk DNA. Subsequent research has revealed that most of the genome is transcribed into a broad array of noncoding RNAs, ranging in size from microRNA (20–23 nucleotides) to long noncoding RNA (lncRNA, more than 200 nucleotides). These noncoding RNA classes have been shown to use diverse molecular mechanisms to control gene expression and organ system development. As anticipated, alterations in this large control system can contribute to disease pathogenesis and carcinogenesis. We review the involvement of noncoding RNAs—lncRNAs in particular—in development of Barrett's esophagus and esophageal carcinoma.
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影响因子：
64.8
作者：
Cancer Genome Atlas Research Network;Analysis Working Group: Asan University;BC Cancer Agency;Brigham and Women’s Hospital;Broad Institute;Brown University;Case Western Reserve University;Dana-Farber Cancer Institute;Duke University;Greater Poland Cancer Centre;Harvard Medical School;Institute for Systems Biology;KU Leuven;Mayo Clinic;Memorial Sloan Kettering Cancer Center;National Cancer Institute;Nationwide Children’s Hospital;Stanford University;University of Alabama;University of Michigan;University of North Carolina;University of Pittsburgh;University of Rochester;University of Southern California;University of Texas MD Anderson Cancer Center;University of Washington;Van Andel Research Institute;Vanderbilt University;Washington University;Genome Sequencing Center: Broad Institute;Washington University in St. Louis;Genome Characterization Centers: BC Cancer Agency;Broad Institute;Harvard Medical School;Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University;University of North Carolina;University of Southern California Epigenome Center;University of Texas MD Anderson Cancer Center;Van Andel Research Institute;Genome Data Analysis Centers: Broad Institute;Brown University:;Harvard Medical School;Institute for Systems Biology;Memorial Sloan Kettering Cancer Center;University of California Santa Cruz;University of Texas MD Anderson Cancer Center;Biospecimen Core Resource: International Genomics Consortium;Research Institute at Nationwide Children’s Hospital;Tissue Source Sites: Analytic Biologic Services;Asan Medical Center;Asterand Bioscience;Barretos Cancer Hospital;BioreclamationIVT;Botkin Municipal Clinic;Chonnam National University Medical School;Christiana Care Health System;Cureline;Duke University;Emory University;Erasmus University;Indiana University School of Medicine;Institute of Oncology of Moldova;International Genomics Consortium;Invidumed;Israelitisches Krankenhaus Hamburg;Keimyung University School of Medicine;Memorial Sloan Kettering Cancer Center;National Cancer Center Goyang;Ontario Tumour Bank;Peter MacCallum Cancer Centre;Pusan National University Medical School;Ribeirão Preto Medical School;St. Joseph’s Hospital &Medical Center;St. Petersburg Academic University;Tayside Tissue Bank;University of Dundee;University of Kansas Medical Center;University of Michigan;University of North Carolina at Chapel Hill;University of Pittsburgh School of Medicine;University of Texas MD Anderson Cancer Center;Disease Working Group: Duke University;Memorial Sloan Kettering Cancer Center;National Cancer Institute;University of Texas MD Anderson Cancer Center;Yonsei University College of Medicine;Data Coordination Center: CSRA Inc.;Project Team: National Institutes of Health
通讯作者：
Project Team: National Institutes of Health
DOI：
10.4292/wjgpt.v5.i3.105
发表时间：
2014-08-06
期刊：
World journal of gastrointestinal pharmacology and therapeutics
影响因子：
--
作者：
Badillo, Raul;Francis, Dawn
通讯作者：
Francis, Dawn
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
10.5
作者：
Dey BK;Pfeifer K;Dutta A
通讯作者：
Dutta A
影响因子：
5.6
作者：
Gurtan, Allan M.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.