Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer.
Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer.
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胃癌肿瘤微环境中肿瘤浸润免疫细胞和免疫相关基因的预后景观
DOI：
10.18632/aging.103519
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发表时间：
2020-09-23
期刊：
影响因子：
--
通讯作者：
Ouyang Y
中科院分区：
文献类型：
--
作者：
Zhang S;Zeng Z;Liu Y;Huang J;Long J;Wang Y;Peng X;Hu Z;Ouyang Y
肿瘤微环境与肿瘤细胞的进展和免疫逃生密切相关。肿瘤浸润的免疫细胞（TIICS）和与免疫相关的基因（IRG）是肿瘤微环境的必不可少的成分，并且已证明在确定多种癌症的预后方面非常有价值。为了阐明TIICS和IRGS在胃癌中的预后价值，我们进行了全面的分析，重点是基于癌症基因组图集（TCGA）的数据集的22种类型的TIICS和差异表达的IRG。结果表明，在不同阶段，TIICS和免疫细胞亚构件的巨大组成差异与生存结果有关。此外，从345个差异表达的IRG中表征了29个集线器基因，并发现与生存结果显着相关。然后，在对某些临床参数的多变量调整后，成功构建了基于十个IRG的独立预后指标。进一步的验证表明，这些枢纽IRG可以反映免疫细胞的浸润水平。因此，我们的结果证实了TIICS和IRGS在胃癌中的临床意义，并可能为进一步探索免疫细胞和个性化治疗的基因靶标建立基础。
The tumor microenvironment is closely related to the progression and immune escape of tumor cells. Tumor-infiltrating immune cells (TIICs) and immune-related genes (IRGs) are indispensable components of the tumor microenvironment and have been demonstrated to be highly valuable in determining the prognosis of multiple cancers. To elucidate the prognostic value of TIICs and IRGs in gastric cancer, we conducted a comprehensive analysis focusing on the abundances of 22 types of TIICs and differentially expressed IRGs based on a dataset from The Cancer Genome Atlas (TCGA). The results showed that great composition differences in TIICs and immune cell subfractions were associated with survival outcomes in different stages. Additionally, 29 hub genes were characterized from 345 differentially expressed IRGs and found to be significantly associated with survival outcomes. Then, an independent prognostic indicator based on ten IRGs was successfully constructed after multivariate adjustment for some clinical parameters. Further validation revealed that these hub IRGs could reflect the infiltration levels of immune cells. Thus, our results confirmed the clinical significance of TIICs and IRGs in gastric cancer and may establish a foundation for further exploring immune cell and gene targets for personalized treatment.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
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Schultz N
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