Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid.
Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid.
复制标题
补充支链氨基酸通过肠道微生物介导的乙酸产生减少肝脏中的脂肪积累。
DOI：
10.1038/s41598-020-75542-3
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发表时间：
2020-10-30
影响因子：
4.6
通讯作者：
Shibata H
中科院分区：
文献类型：
--
作者：
Iwao M;Gotoh K;Arakawa M;Endo M;Honda K;Seike M;Murakami K;Shibata H
非酒精性脂肪性肝病（NAFLD）是一个重要的问题，因为它的患病率在世界范围内不断增加。最近的动物研究已经确定肠道微生物群在NAFLD的发病机制中具有潜在的重要作用。以前，我们报道了支链氨基酸（BCAAs）的管理减少实验动物模型中的肝脏脂肪堆积。本研究旨在阐明支链氨基酸给药后肠道微生物植物群的变化如何影响高脂饮食（HF）诱导的肝脏脂肪蓄积。我们研究了支链氨基酸的施用是否改变了肝脏脂肪积聚的发展以及肠道微生物植物群。BCAAs（3%千卡）的口服给药诱导产黄瘤胃球菌（R. flavefaciens）和门静脉乙酸水平，并减少HF喂养大鼠的肝脏脂肪积累。此外，支链氨基酸降低了肝脏中脂肪生成相关基因FAS和ACC的表达。此外，我们还观察到R. flavefaciens对于促进BCAA诱导的肝脂肪积累的减少是必需的。这些数据表明，支链氨基酸处理诱导肠道植物群的增殖，包括R。由肠道植物群合成的门静脉乙酸通过下调肝脏中FAS和ACC的表达来改善NAFLD。
Non-alcoholic fatty liver disease (NAFLD) is a significant problem because its prevalence is increasing worldwide. Recent animal studies have identified gut microbiota as a potentially important player in the pathogenesis of NAFLD. Previously, we reported that the administration of branched-chain amino acids (BCAAs) reduces hepatic fat accumulation in experimental animal models. This study aimed to clarify how changes in the intestinal microbial flora following the administration of BCAAs affect a high-fat diet (HF)-induced fat accumulation in the liver. We examined whether the administration of BCAAs alters the development of hepatic fat accumulation as well as intestinal microbial flora. The oral administration of BCAAs (3% kcal) induced a significant increase in Ruminococcus flavefaciens (R. flavefaciens) and portal acetic acid levels, and it reduced hepatic fat accumulation in HF-fed rats. In addition, BCAAs reduced the expression of the lipogenesis-related genes FAS and ACC in the liver. Furthermore, we observed that R. flavefaciens is essential for promoting a BCAA-induced reduction in hepatic fat accumulation. These data suggest that BCAA treatment induces the proliferation of intestinal flora including R. flavefaciens and that portal acetic acid synthesized from intestinal flora improves NAFLD by downregulating the expression of FAS and ACC in the liver.
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肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪积累。
影响因子：
16.6
作者：
通讯作者：
--
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
12.6
作者：
Muto, Y;Sato, S;Kumada, H
通讯作者：
Kumada, H
影响因子：
9.8
作者：
Buzzetti, Elena;Pinzani, Massimo;Tsochatzis, Emmanuel A.
通讯作者：
Tsochatzis, Emmanuel A.
影响因子：
3
作者：
Gokarn, RR;Eiteman, MA;Eriksson, KEL
通讯作者：
Eriksson, KEL