Remodeling of host membranes during herpesvirus assembly and egress.
Remodeling of host membranes during herpesvirus assembly and egress.
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疱疹病毒组装和排出过程中宿主膜的重塑
DOI：
10.1007/s13238-018-0577-9
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发表时间：
2019-05
期刊：
影响因子：
21.1
通讯作者：
Deng H
中科院分区：
文献类型：
--
作者：
Lv Y;Zhou S;Gao S;Deng H
许多病毒，无论是有包膜的还是无包膜的，都会为了复制、组装和逃离宿主细胞而重塑宿主膜结构。疱疹病毒是人类重要的病原体，可引起多种疾病。作为大包膜DNA病毒，疱疹病毒经历了几个复杂的步骤来完成它们的生命周期并产生具有感染性的后代。首先，疱疹病毒的组装在细胞核中启动，产生的核衣壳太大，无法穿过核孔。新生的核衣壳在内核膜上发芽，在核周空间形成初级包膜病毒粒子，然后初级包膜与外核膜融合，将核衣壳移位到细胞质中。其次，核衣壳在细胞质中获得一系列的被蛋白，芽进入来自宿主细胞器的囊泡以获得病毒包膜。然后，囊泡被运输到质膜并与质膜融合，将成熟的病毒粒子释放到细胞外空间。因此，在疱疹病毒组装和输出过程中，细胞膜结构上至少会发生两次萌发和融合事件，导致细胞膜变形。在这篇综述中，我们描述和讨论了疱疹病毒如何利用和重塑宿主膜结构来组装和逃离宿主细胞。
Many viruses, enveloped or non-enveloped, remodel host membrane structures for their replication, assembly and escape from host cells. Herpesviruses are important human pathogens and cause many diseases. As large enveloped DNA viruses, herpesviruses undergo several complex steps to complete their life cycles and produce infectious progenies. Firstly, herpesvirus assembly initiates in the nucleus, producing nucleocapsids that are too large to cross through the nuclear pores. Nascent nucleocapsids instead bud at the inner nuclear membrane to form primary enveloped virions in the perinuclear space followed by fusion of the primary envelopes with the outer nuclear membrane, to translocate the nucleocapsids into the cytoplasm. Secondly, nucleocapsids obtain a series of tegument proteins in the cytoplasm and bud into vesicles derived from host organelles to acquire viral envelopes. The vesicles are then transported to and fuse with the plasma membrane to release the mature virions to the extracellular space. Therefore, at least two budding and fusion events take place at cellular membrane structures during herpesviruses assembly and egress, which induce membrane deformations. In this review, we describe and discuss how herpesviruses exploit and remodel host membrane structures to assemble and escape from the host cell.
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
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通讯作者：
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