Comparing two classification schemes for seizures and epilepsy in rural China.
Comparing two classification schemes for seizures and epilepsy in rural China.
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DOI：
10.1111/ene.13857
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发表时间：
2019-03
影响因子：
5.1
通讯作者：
Kwan P
中科院分区：
文献类型：
--
作者：
Wang F;Chen Z;Davagnanam I;Hoskote C;Ding D;Wang W;Yang B;Wang Y;Wang T;Li W;Sander JW;Kwan P
国际抗癫痫联盟（ILAE）于2017年更新了癫痫发作和癫痫的分类。我们将2017年的分类与20世纪80年代中国农村的分类进行了比较。癫痫患者来自中国农村地区，接受国家癫痫控制计划的治疗。他们的癫痫发作和癫痫综合征使用1980年的ILAE分类系统进行分类，然后根据2017年的系统重新分类。鉴别了癫痫发作、癫痫和病因学分类的差异。共纳入597名个体（58%为男性，年龄6-78岁）。其中535例（90%）为单一发作类型，57例（9.55%）为两种发作类型，5例（0.84%）为三种发作类型。1981年和2017年对525名有局灶性癫痫发作的人的分类完全一致。在2017年的分类中，65名患者中有10人的癫痫发作最初被归类为全身性发作，但被重新归类为未知。与1980年代的分类相比，不明原因发作和不明原因癫痫的比例从1.2%（7/597）上升到2.8%（17/597，p=0.002），未知病因从32%（189/597：182个隐源性和7个未分类）到2017年分类中的39%（230/597; p<0.001）。20世纪80年代和2017年的分类在中国农村地区的局灶性癫痫发作和癫痫分类方面具有100%的一致性。在旧分类中分类的全身性癫痫发作和癫痫以及病因在新分类中重新分类为未知的比例很小但很大。这些结果强调了需要改善癫痫患者在资源匮乏的环境中的临床评价。
The International League Against Epilepsy (ILAE) updated the classifications of seizures and epilepsies in 2017. We compared the 2017 classifications with the 1980’s classifications in rural China. People with epilepsy were recruited from rural areas in China receiving treatment under the National Epilepsy Control Programme. Their seizures and epileptic syndrome were classified using the 1980’s ILAE classification system and then re-classified according the 2017 system. Differences in seizure, epilepsy and aetiology classifications were identified. A total of 597 individuals (58% males, aged 6–78 years) were included. Among them 535 (90%) had a single seizure type, 57 (9.55%) had two types, and five (0.84%) had three. There was complete agreement between the 1981 and 2017 classifications for the 525 individuals with focal seizures. Seizures originally classified as generalised in 10 of 65 individuals were re-classified as unknown in the 2017 classifications. Compared to the 1980’s classifications, the proportion of individuals with unknown seizures and unknown epilepsy increased from 1.2% (7/597) to 2.8% (17/597, p=0.002), and unknown aetiology increased from 32% (189/597: 182 cryptogenic and seven unclassified) to 39% (230/597; p<0.001) in the 2017 classifications. The 1980’s and 2017 classifications had 100% agreement in classifying focal seizures and epilepsy in rural China. A small but significant proportion of generalised seizures and epilepsy and aetiologies classified in the old classifications were re-classified to unknown in the new classifications. These results highlight the need for improvement in clinical evaluation of people with epilepsy in resource-poor settings.
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影响因子：
5.6
作者：
BANCAUD, J;HENRIKSEN, O;PENRY, JK
通讯作者：
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影响因子：
5.6
作者：
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影响因子：
5.6
作者：
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通讯作者：
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