Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy.
Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy.
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DOI：
10.1016/j.biomaterials.2017.11.025
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发表时间：
2018-03
期刊：
影响因子：
14
通讯作者：
Pu K
中科院分区：
文献类型：
--
作者：
Li J;Rao J;Pu K
半导体聚合物纳米粒子(SPN)作为一类新型的有机光学纳米材料，具有优良的光学性能、高的光稳定性和易实现表面功能化等优点，在生物医学领域具有良好的生物相容性。本文综述了近年来用于分子成像和肿瘤光疗的SPN的设计和合成的研究进展。各种新型聚合物设计、化学修饰和纳米工程策略已被开发出来，以精确调整SPN的光电性质，使其能够在活体动物中进行荧光、化学发光和光声(PA)成像。通过这些成像方式，SPN不仅可以成像淋巴结、血管结构和肿瘤等组织，还可以检测疾病生物标记物，如活性氧(ROS)和蛋白质磺酸，以及生理指标，如pH和血糖浓度。并举例说明了SPN在肿瘤光疗中的应用潜力，包括光动力疗法和光热疗法。未来的努力应该进一步扩大SPN在生物医学研究中的使用，甚至可能使它们超越临床前研究。
As a new class of organic optical nanomaterials, semiconducting polymer nanoparticles (SPNs) have the advantages of excellent optical properties, high photostability and facile surface functionalization, and are considered to possess good biocompatibility for biomedical applications. This review surveys recent progress made on the design and synthesis of SPNs for molecular imaging and cancer phototherapy. A variety of novel polymer design, chemical modification and nanoengineering strategies have been developed to precisely tune up optoelectronic properties of SPNs to enable fluorescence, chemiluminescence and photoacoustic (PA) imaging in living animals. With these imaging modalities, SPNs have been demonstrated not only to image tissues such as lymph nodes, vascular structure and tumors, but also to detect disease biomarkers such as reactive oxygen species (ROS) and protein sulfenic acid as well as physiological indexes such as pH and blood glucose concentration. The potentials of SPNs in cancer phototherapy including photodynamic and photothermal therapy are also highlighted with recent examples. Future efforts should further expand the use of SPNs in biomedical research and may even move them beyond pre-clinical studies.
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