Effects of negative stressors on DNA methylation in the brain: implications for mood and anxiety disorders.
Effects of negative stressors on DNA methylation in the brain: implications for mood and anxiety disorders.
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DOI：
10.1002/ajmg.b.32265
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发表时间：
2014-10
影响因子：
2.8
通讯作者：
Potash, James B.
中科院分区：
文献类型：
--
作者：
Hing, Benjamin;Gardner, Caleb;Potash, James B.
压力是焦虑和情绪障碍的主要原因。最近发现的表观遗传变化，在大脑中造成的压力，加强了我们的理解的机制，压力是能够促进这些疾病。虽然表观遗传学包括发生在DNA和组蛋白上的化学修饰，但许多注意力都集中在应激诱导的DNA甲基化对行为的影响上。在这里，我们回顾了应激诱导的DNA甲基化变化对控制行为和认知的生理机制的影响，其失调可能对心理健康有害。在DNA甲基化，压力及其对大脑和精神疾病的影响方面进行了文献综述。关键发现集中在下丘脑-垂体-肾上腺轴、神经传递和神经可塑性的基因上。使用不同的压力范例和临床研究的动物模型，我们详细介绍了这些基因的DNA甲基化变化如何改变影响行为的生理机制。大脑中适当的基因表达水平对心理健康起着重要作用。这种动态控制可以被应激诱导的DNA甲基化模式的变化所破坏。在表观遗传学的其他领域的进展，如组蛋白修饰和新的DNA表观遗传标记，5-羟甲基胞嘧啶的发现，可以提供额外的途径来考虑确定压力对大脑的表观遗传影响。
Stress is a major contributor to anxiety and mood disorders. The recent discovery of epigenetic changes in the brain resulting from stress has enhanced our understanding of the mechanism by which stress is able to promote these disorders. Although epigenetics encompasses chemical modifications that occur at both DNA and histones, much attention has been focused on stress-induced DNA methylation changes on behavior. Here, we review the effect of stress-induced DNA methylation changes on physiological mechanisms that govern behavior and cognition, dysregulation of which can be harmful to mental health. A literature review was performed in the areas of DNA methylation, stress, and their impact on the brain and psychiatric illness. Key findings center on genes involved in the hypothalamic-pituitary-adrenal axis, neurotransmission and neuroplasticity. Using animal models of different stress paradigms and clinical studies, we detail how DNA methylation changes to these genes can alter physiological mechanisms that influence behavior. Appropriate levels of gene expression in the brain play an important role in mental health. This dynamic control can be disrupted by stress-induced changes to DNA methylation patterns. Advancement in other areas of epigenetics, such as histone modifications and the discovery of the novel DNA epigenetic mark, 5-hydroxymethylcytosine, could provide additional avenues to consider when determining the epigenetic effects of stress on the brain.
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影响因子：
64.5
作者：
Bhutani N;Burns DM;Blau HM
通讯作者：
Blau HM
影响因子：
4.4
作者：
Culverhouse, Robert C.;Bowes, Lucy;Bierut, Laura J.
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30.8
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Muller-Myhsok, B
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25
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通讯作者：
Ressier, Kerry J.
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2.5
作者：
Cunha, Angelo B. M.;Frey, Benicio N.;Kapczinski, Flavio
通讯作者：
Kapczinski, Flavio