Dietary Fructose Increases the Sensitivity of Proximal Tubules to Angiotensin II in Rats Fed High-Salt Diets.
Dietary Fructose Increases the Sensitivity of Proximal Tubules to Angiotensin II in Rats Fed High-Salt Diets.
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DOI：
10.3390/nu10091244
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发表时间：
2018-09-06
期刊：
影响因子：
5.9
通讯作者：
Garvin JL
中科院分区：
文献类型：
--
作者：
Gonzalez-Vicente A;Hong NJ;Yang N;Cabral PD;Berthiaume JM;Dominici FP;Garvin JL
Dietary fructose causes salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the filtered NaCl. Angiotensin II (Ang II), atrial natriuretic peptide (ANP) and norepinephrine (NE) regulate this process. Although Ang II signaling blockade ameliorates fructose-induced salt-sensitive hypertension, basal PT Na+ reabsorption and its sensitivity to the aforementioned factors have not been studied in this model. We hypothesized consuming fructose with a high-salt diet selectively enhances the sensitivity of PT transport to Ang II. We investigated the effects of Ang II, ANP and NE on PT Na reabsorption in rats fed a high-salt diet drinking tap water (HS) or 20% fructose (HS-FRU). Oxygen consumption (QO2) was used as a measure of all ATP-dependent transport processes. Na+/K+-ATPase and Na+/H+-exchange (NHE) activities were studied because they represent primary apical and basolateral transporters in this segment. The effect of 10−12 mol/L Ang II in QO2 by PTs from HS-FRU was larger than HS (p < 0.02; n = 7). In PTs from HS-FRU 10−12 mol/L Ang II stimulated NHE activity by 2.6 ± 0.7 arbitrary fluorescence units/s (p < 0.01; n = 5) but not in those from HS. The stimulatory effect of Ang II on PT Na+/K+-ATPase activity was not affected by HS-FRU. Responses of QO2 and NHE activity to ANP did not differ between groups. The response of QO2 to NE was unaltered by HS-FRU. We concluded that the sensitivity of PT Na+ reabsorption specifically to Ang II is enhanced by HS-FRU. This maintains high rates of transport even in the presence of low concentrations of the peptide, and likely contributes to the hypertension.
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影响因子：
2.5
作者：
Gordish KL;Kassem KM;Ortiz PA;Beierwaltes WH
通讯作者：
Beierwaltes WH
影响因子：
5.9
作者：
Gonzalez-Vicente A;Cabral PD;Hong NJ;Asirwatham J;Yang N;Berthiaume JM;Dominici FP;Garvin JL
通讯作者：
Garvin JL
DOI：
10.1152/ajprenal.00064.2013
发表时间：
2013-11-01
影响因子：
4.2
作者：
Gonzalez-Vicente, Agustin;Garvin, Jeffrey L.
通讯作者：
Garvin, Jeffrey L.
影响因子：
--
作者：
GOMES, GN;AIRES, MM
通讯作者：
AIRES, MM
DOI：
10.1152/ajpregu.00680.2007
发表时间：
2008-03-01
影响因子：
2.8
作者：
Brown, Clive M.;Dulloo, Abdul G.;Montani, Jean-Pierre
通讯作者：
Montani, Jean-Pierre