Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.
Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.
复制标题
DOI：
10.1371/journal.pone.0193731
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Oike Y
中科院分区：
文献类型：
--
作者：
Morinaga J;Zhao J;Endo M;Kadomatsu T;Miyata K;Sugizaki T;Okadome Y;Tian Z;Horiguchi H;Miyashita K;Maruyama N;Mukoyama M;Oike Y
据报道，血管生成素样蛋白（ANGPTLs）3、4和8有助于代谢疾病的进展，代谢疾病是心血管疾病（CVD）的危险因素。本研究的目的是调查在调整潜在混杂因素后，循环ANGPTL水平是否与CVD风险相关。我们对988名接受常规健康检查的日本受试者进行了一项单中心横断面研究。血清ANGPTL 3，4和8水平使用酶联免疫吸附测定法进行测量。使用多元回归分析，我们评估了循环ANGPTL 3、4和8水平与一般医学状况的潜在相关性，包括年龄、性别、吸烟、饮酒、肥胖、高血压、糖代谢受损、血脂异常、高尿酸血症、肝损害、慢性肾病、贫血、心脏异常和炎症。循环ANGPTL 3水平在健康相关的肝损伤和炎症类别中相对较高。循环ANGPTL 4水平在糖代谢受损或肝损害中也显著高，但在炎症中降低。最后，在肥胖、糖代谢受损和血脂异常中观察到ANGPTL 8水平增加。特别地，循环ANGPTL 8水平的增加与循环甘油三酯和LDL-胆固醇水平正相关，与循环HDL-胆固醇水平负相关。循环ANGPTL 3、4和8水平反映了CVD发展的一些风险因素。
Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 reportedly contribute to progression of metabolic disease, a risk factor for cardiovascular disease (CVD). The purpose of this study was to investigate whether circulating ANGPTL levels are associated with CVD risk after adjustment for potential confounding factors. We conducted a single center, cross-sectional study of 988 Japanese subjects undergoing routine health checks. Serum ANGPTL3, 4, and 8 levels were measured using an enzyme-linked immunosorbent assay. Using multiple regression analysis we evaluated potential association of circulating ANGPTL3, 4, and 8 levels with general medical status including age, sex, smoking, drinking, obesity, hypertension, impaired glycometabolism, dyslipidemia, hyperuricemia, hepatic impairment, chronic kidney disease, anemia, cardiac abnormality, and inflammation. Circulating ANGPTL3 levels were relatively high in health-related categories of hepatic impairment and inflammation. Circulating ANGPTL4 levels were also significantly high in impaired glycometabolism or hepatic impairment but decreased in inflammation. Finally, increased ANGPTL8 levels were observed in obesity, impaired glycometabolism and dyslipidemia. Particularly, increased levels of circulating ANGPTL8 were positively correlated with circulating triglycerides and LDL-cholesterol levels and inversely correlated with circulating HDL-cholesterol levels. Circulating ANGPTL3, 4, and 8 levels reflect some risk factors for CVD development.
登录
查看更多内容
DOI：
10.1161/atvbaha.113.302802
发表时间：
2014-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Mehta N;Qamar A;Qu L;Qasim AN;Mehta NN;Reilly MP;Rader DJ
通讯作者：
Rader DJ
运动和PGC1alpha在炎症和慢性疾病中的作用。
影响因子：
64.8
作者：
Handschin, Christoph;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
29
作者：
Lichtenstein L;Mattijssen F;de Wit NJ;Georgiadi A;Hooiveld GJ;van der Meer R;He Y;Qi L;Köster A;Tamsma JT;Tan NS;Müller M;Kersten S
通讯作者：
Kersten S
影响因子：
4.5
作者：
Abu-Farha M;Al-Khairi I;Cherian P;Chandy B;Sriraman D;Alhubail A;Al-Refaei F;AlTerki A;Abubaker J
通讯作者：
Abubaker J
影响因子：
4.8
作者：
Mandard, S;Zandbergen, F;Kersten, S
通讯作者：
Kersten, S