The role of exercise and PGC1alpha in inflammation and chronic disease.
The role of exercise and PGC1alpha in inflammation and chronic disease.
复制标题
运动和PGC1alpha在炎症和慢性疾病中的作用。
DOI:
10.1038/nature07206
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发表时间:
2008-07-24
期刊:
影响因子:
64.8
通讯作者:
Spiegelman, Bruce M.
中科院分区:
文献类型:
--
作者:
Handschin, Christoph;Spiegelman, Bruce M.
Inadequate physical activity is linked to many chronic diseases. However, the mechanisms that tie muscle activity to health are unclear. The peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) controls several exercise-related aspects of muscle function. We propose here mechanisms by which this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
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