The role of exercise and PGC1alpha in inflammation and chronic disease.

The role of exercise and PGC1alpha in inflammation and chronic disease.
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运动和PGC1alpha在炎症和慢性疾病中的作用。

DOI:
10.1038/nature07206
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发表时间:
2008-07-24
期刊:
影响因子:
64.8
通讯作者:
Spiegelman, Bruce M.
Spiegelman, Bruce M.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Handschin, Christoph;Spiegelman, Bruce M.

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身体活动不足与许多慢性疾病有关。然而,将肌肉活动与健康联系起来的机制尚不清楚。过氧化物酶体增殖物激活受体γ共激活因子1α(PGC-1α)控制肌肉功能的几个运动相关方面。我们在这里提出了这种蛋白质控制肌肉可塑性,抑制广泛的炎症反应和介导运动的有益作用的机制。
Inadequate physical activity is linked to many chronic diseases. However, the mechanisms that tie muscle activity to health are unclear. The peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) controls several exercise-related aspects of muscle function. We propose here mechanisms by which this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
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