The role of ghrelin, salivary secretions, and dental care in eating disorders.
The role of ghrelin, salivary secretions, and dental care in eating disorders.
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作者：
Yagi T;Ueda H;Amitani H;Asakawa A;Miyawaki S;Inui A
饮食失调，包括厌食症和神经性贪食症，是潜在的危及生命的综合征，其特征是饮食行为的严重紊乱。对于这些情况，有效的治疗策略仍有待建立，因为饮食失调患者往往会多次复发。由于胃饥饿素最初是在胃粘膜中发现的，因此在过去的十年中，人们对其进行了广泛的研究，以揭示其潜在的作用；这些研究揭示了胃饥饿素调节食物摄入的机制。因此，在饮食失调的背景下研究胃饥饿素可以提高我们对饮食失调发病机制的理解，可能为这些患者提供有希望的新药物治疗策略。此外，早期发现和治疗饮食失调对于确保年轻患者的康复至关重要。口腔症状，包括粘膜、牙齿和唾液异常，通常在饮食失调的早期阶段观察到。虽然口腔护理与饮食失调的治疗没有直接关系，但了解饮食失调患者的口腔表现可能有助于早期发现，从而早期治疗；因此，口腔护理可能有助于患者的整体管理和预后。此外，在唾液中也发现了胃饥饿素，它可能负责口腔卫生和消化相关功能。本文综述了胃饥饿素在调节食物摄入中的药理潜力，以及在年轻饮食失调患者中唾液和口腔护理的作用。
Eating disorders, including anorexia and bulimia nervosa, are potentially life-threatening syndromes characterized by severe disturbances in eating behavior. An effective treatment strategy for these conditions remains to be established, as patients with eating disorders tend to suffer from multiple relapses. Because ghrelin was originally discovered in the stomach mucosa, it has been widely studied over the past decade in an effort to uncover its potential roles; these studies have shed light on the mechanism by which ghrelin regulates food intake. Thus, studying ghrelin in the context of eating disorders could improve our understanding of the pathogenesis of eating disorders, possibly resulting in a promising new pharmacological treatment strategy for these patients. In addition, early detection and treatment of eating disorders are critical for ensuring recovery of young patients. Oral symptoms, including mucosal, dental, and saliva abnormalities, are typically observed in the early stages of eating disorders. Although oral care is not directly related to the treatment of eating disorders, knowledge of the oral manifestations of eating disorder patients may aid in early detection, resulting in earlier treatment; thus, oral care might contribute to overall patient management and prognosis. Moreover, ghrelin has also been found in saliva, which may be responsible for oral hygiene and digestion-related functions. This review discusses the pharmacological potential of ghrelin in regulating food-intake and the role of saliva and oral care in young patients with eating disorders.
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影响因子：
29.4
作者：
Date, Y;Murakami, N;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
5.1
作者：
CRISP, AH
通讯作者：
CRISP, AH
影响因子：
--
作者：
Brzozowski, T;Konturek, PC;Hahn, EG
通讯作者：
Hahn, EG
影响因子：
4.8
作者：
Ariyasu, H;Takaya, K;Nakao, K
通讯作者：
Nakao, K
DOI：
10.1111/j.1475-097x.1996.tb00731.x
发表时间：
1996-07-01
期刊：
CLINICAL PHYSIOLOGY
影响因子：
--
作者：
Chatterton, RT;Vogelsong, KM;Hudgens, GA
通讯作者：
Hudgens, GA