Gelatinase A is a glomerular mesangial cell growth and differentiation factor.

Gelatinase A is a glomerular mesangial cell growth and differentiation factor.
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明胶酶 A 是一种肾小球系膜细胞生长和分化因子。

DOI:
10.1038/ki.1997.191
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发表时间:
1997
影响因子:
19.6
通讯作者:
Lovett,DH
Lovett,DH
中科院分区:
医学1区
文献类型:
--
作者:
Turck,J;Pollock,AS;Lovett,DH

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Gelatinase A is a glomerular mesangial cell growth and differentiation factor.The members of the matrix metalloproteinase gene family play critical roles in numerous physiologic events, including cellular migration, tissue remodeling in wound healing and development, as well as in the evolution of the inflammatory process. The 72 kDa gelatinase A (formerly denoted 72 kDa Type IV collagenase) is centrally involved in the inflammatory and sclerotic events common to most forms of chronic glomerular disease. In this article recent studies are summarized which demonstrate that this particular enzyme can directly affect the proliferative and differentiation properties of the intrinsic glomerular mesangial cell, bothin vitroandin vivo.
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