Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models.
Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models.
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DOI：
10.1371/journal.pone.0089229
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Garcia-Alloza M
中科院分区：
文献类型：
--
作者：
Ramos-Rodriguez JJ;Molina-Gil S;Ortiz-Barajas O;Jimenez-Palomares M;Perdomo G;Cozar-Castellano I;Lechuga-Sancho AM;Garcia-Alloza M
2型糖尿病（T2 D）是痴呆（包括阿尔茨海默病（AD））的重要危险因素，并且在痴呆中观察到的一些神经病理学特征可由T2 D代谢改变介导。由于T2 D和AD均观察到脑萎缩和神经发生受损，我们分析了作为长期胰岛素抵抗和T2 D模型的db/db小鼠（瘦素受体KO小鼠）和C57 B16小鼠的中枢神经系统（CNS）形态学变化。喂食高脂肪饮食（HFD）作为饮食诱导的胰岛素抵抗和糖尿病前期模型。Db/db小鼠表现出年龄依赖性皮质和海马萎缩，而在HFD小鼠皮质和海马被保留。我们还检测到增加的神经发生和细胞增殖率在年轻的db/db小鼠相比，对照同窝出生。我们的研究表明，代谢参数作为预测的萎缩和改变增殖和神经发生在中枢神经系统。此外，在皮质，萎缩，细胞增殖和神经发生显着相关。我们的数据表明，T2 D可能强调了在痴呆过程中观察到的一些病理特征。他们还支持老年患者的血糖控制有助于减缓痴呆症的演变，并可能改善其预后。
Type 2 diabetes (T2D) is an important risk factor to suffer dementia, including Alzheimer’s disease (AD), and some neuropathological features observed in dementia could be mediated by T2D metabolic alterations. Since brain atrophy and impaired neurogenesis have been observed both T2D and AD we analyzed central nervous system (CNS) morphological alterations in the db/db mice (leptin receptor KO mice), as a model of long-term insulin resistance and T2D, and in C57Bl6 mice fed with high fat diet (HFD), as a model of diet induced insulin resistance and prediabetes. Db/db mice showed an age-dependent cortical and hippocampal atrophy, whereas in HFD mice cortex and hippocampus were preserved. We also detected increased neurogenesis and cell proliferation rates in young db/db mice when compared with control littermates. Our study shows that metabolic parameters serve as predictors of both atrophy and altered proliferation and neurogenesis in the CNS. Moreover in the cortex, atrophy, cell proliferation and neurogenesis were significantly correlated. Our data suggest that T2D may underline some of the pathological features observed in the dementia process. They also support that blood glucose control in elderly patients could help to slow down dementia evolution and maybe, improve its prognosis.
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影响因子：
--
作者：
Craft, Suzanne
通讯作者：
Craft, Suzanne
影响因子：
3.7
作者：
Jose Ramos-Rodriguez, Juan;Ortiz, Oscar;Garcia-Alloza, Monica
通讯作者：
Garcia-Alloza, Monica
DOI：
10.1097/nen.0b013e318288a8dd
发表时间：
2013-04-01
影响因子：
3.2
作者：
Jose Ramos-Rodriguez, Juan;Pacheco-Herrero, Mar;Garcia-Alloza, Monica
通讯作者：
Garcia-Alloza, Monica
影响因子：
4.2
作者：
Hamilton, A.;Patterson, S.;Holscher, C.
通讯作者：
Holscher, C.
影响因子：
3.7
作者：
Dinel AL;André C;Aubert A;Ferreira G;Layé S;Castanon N
通讯作者：
Castanon N