Distribution but not amount of protein intake is associated with frailty: a cross-sectional investigation in the region of Nürnberg.
Distribution but not amount of protein intake is associated with frailty: a cross-sectional investigation in the region of Nürnberg.
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DOI：
10.1186/1475-2891-12-109
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发表时间：
2013-08-05
影响因子：
5.4
通讯作者：
Volkert D
中科院分区：
文献类型：
--
作者：
Bollwein J;Diekmann R;Kaiser MJ;Bauer JM;Uter W;Sieber CC;Volkert D
为了保持肌肉质量，从而限制老年人残疾的风险，蛋白质摄入被视为一个重要因素。除了蛋白质的数量，它在一天中的分布被认为会影响蛋白质的合成代谢。这项横断面研究调查了老年人蛋白质摄入量和分布与虚弱之间的关系。采用食物频率问卷对194名≥75岁的社区老年人的蛋白质摄入量及其在一天（早、中、晚）中的分布进行了评估。蛋白质分布的不均匀性以变异系数（CV）计算。虚弱被定义为至少存在三项，前虚弱被定义为存在以下一项或两项标准：体重减轻，疲惫，体力活动少，握力低和行走速度慢。15.4%的参与者体弱，40.5%的参与者体弱前期。每日蛋白质摄入量中位数（最小-最大）分别为77.5 (38.5-131.5)g/kg体重（BW）、1.07 (0.58-2.27)g/kg体重（BW）和15.9 (11.2 - 21.8%)% /kg体重（BW），虚弱组之间无显著差异。蛋白质摄入量高四分位数的参与者与最低四分位数的参与者相比，身体虚弱的风险没有显著差异。虚弱的参与者在早上摄入的蛋白质明显较少（11.9 vs. 14.9 vs. 17.4%, p = 0,007），但在中午（61.4 vs. 60.8 vs. 55.3%, p = 0.024）比虚弱前和非虚弱者摄入的蛋白质更多。中位数（min.-max.）体弱者的蛋白质分布CV（0.76(0.18-1.33)）高于体弱前（0.74(0.07-1.29)）和非体弱者（0.68 (0.15-1.24)）（p = 0.024）。在这组健康老年人样本中，蛋白质摄入量与虚弱无关，但蛋白质摄入量的分布在虚弱、虚弱前期和非虚弱的参与者之间存在显著差异。需要更多的临床研究来进一步阐明蛋白质摄入与虚弱之间的关系。
To preserve muscle mass and therefore limit the risk of disability in older adults protein intake is seen as important factor. Besides the amount of protein, its distribution over the day is thought to affect protein anabolism. This cross-sectional study investigates the association between the amount and distribution of protein intake and frailty in older adults. In 194 community-dwelling seniors (≥75 years) amount of protein intake and its distribution over the day (morning, noon, evening) were assessed using a food frequency questionnaire. Unevenness of protein distribution was calculated as coefficient of variation (CV). Frailty was defined as the presence of at least three, pre-frailty as the presence of one or two of the following criteria: weight loss, exhaustion, low physical activity, low handgrip strength and slow walking speed. 15.4% of the participants were frail, 40.5% were pre-frail. Median (min.-max.) daily protein intake was 77.5 (38.5–131.5) g, 1.07 (0.58–2.27) g/kg body weight (BW) and 15.9 (11.2–21.8) % of energy intake without significant differences between the frailty groups. The risk of frailty did not differ significantly between participants in the higher compared to the lowest quartile of protein intake. Frail participants consumed significantly less protein in the morning (11.9 vs. 14.9 vs. 17.4%, p = 0,007), but more at noon (61.4 vs. 60.8 vs. 55.3%, p = 0.024) than pre-frail and non-frail. The median (min.-max.) CV of protein distribution was highest in frail (0.76 (0.18–1.33)) compared to pre-frail (0.74 (0.07–1.29)) and non-frail (0.68 (0.15–1.24)) subjects (p = 0.024). In this sample of healthy older persons, amount of protein intake was not associated with frailty, but distribution of protein intake was significantly different between frail, pre-frail and non-frail participants. More clinical studies are needed to further clarify the relation between protein intake and frailty.
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DOI：
10.1016/0021-9681(78)90058-9
发表时间：
1978-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
TAYLOR, HL;JACOBS, DR;DEBACKER, G
通讯作者：
DEBACKER, G
DOI：
10.1093/gerona/61.6.589
发表时间：
2006-06-01
影响因子：
5.1
作者：
Bartali, Benedetta;Frongillo, Edward A.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
3.6
作者：
Rousset, S;Mirand, PP;Boirie, Y
通讯作者：
Boirie, Y
影响因子：
6.3
作者：
Robinson SM;Jameson KA;Batelaan SF;Martin HJ;Syddall HE;Dennison EM;Cooper C;Sayer AA;Hertfordshire Cohort Study Group
通讯作者：
Hertfordshire Cohort Study Group
影响因子：
13.6
作者：
Dehne, LI;Klemm, C;Hermann-Kunz, E
通讯作者：
Hermann-Kunz, E