Intrathecal humoral immunologic response in neurologically symptomatic and asymptomatic patients with human immunodeficiency virus infection
Intrathecal humoral immunologic response in neurologically symptomatic and asymptomatic patients with human immunodeficiency virus infection
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有神经系统症状和无症状的人类免疫缺陷病毒感染患者的鞘内体液免疫反应
作者：
I. Elovaara;I. Seppälä;E. Poutiainen;J. Suni;S. Valle
我们分析了42例人类免疫缺陷病毒（HIV）感染患者的鞘内体液免疫反应。18例患者有临床神经系统异常，而其余24例患者无神经系统异常。在早期感染的神经系统症状的患者中，有9例有轻微的神经功能障碍;在晚期感染的其他9例受试者中，神经功能障碍为中度或重度。当与无脑梗死患者相比时，神经系统症状患者的血脑屏障（BBB）内HIV特异性IgG（p < 0.001）和总IgG合成（p < 0.01）增加，CSF和/或血清中的寡克隆条带（OCB）（11/18 vs 3/24）。在感染的早期阶段，有神经系统症状的患者表现出鞘内IgG总合成增加（9/9），与CSF和血清中的OCB一致（7/9），以及轻微的单核细胞增多（7/9），但CNS内HIV特异性IgG产生频率较低（6/9）。在晚期感染中，鞘内HIV特异性IgG合成的神经系统症状患者（8/9）的数量高于早期感染，而BBB内总IgG合成增加（5/9;p < 0.01）、OCB（4/9）和CSF白细胞计数增加（1/9; p < 0.001）的患者数量低于早期感染。我们的数据表明，在HIV感染的早期阶段，体液内BB B免疫活化，随后在晚期感染时CNS内B细胞反应下降。
We analyzed the intrathecal humoral immunologic response in 42 human immunodeficiency virus (HIV)-infected patients. Eighteen patients had clinical neurologic abnormalities, while the remaining 24 patients were neurologically symptom-free. Nine of the neurologically symptomatic patients at early infection had slight neurologic dysfunction; in nine other subjects at late infection, the neurologic impairment was moderate or severe. When compared with symptom-free patients, neurologically symptomatic patients had increased intra-blood-brain barrier (BBB) HIV-specific IgG (p < 0.001) and total IgG synthesis (p < 0.01) with oligoclonal bands (OCBs) in the CSF and/or serum (11/18 versus 3/24). At early stages of the infection, neurologically symptomatic patients showed increased total intrathecal IgG synthesis (9/9) coincident with OCBs in the CSF and serum (7/9) and slight mononuclear pleocytosis (7/9), but less frequent HIV-specific IgG production within the CNS (6/9). In advanced infection, the number of neurologically symptomatic patients with intrathecal HIV-specific IgG synthesis (8/9) was higher, while the number of those with increased total intra-BBB IgG synthesis (5/9;p < 0.01), OCBs (4/9), and increased CSF leukocyte count (1/9; p < 0.001) was lower than at early infection. Our data suggest humoral intra-BBB immunoactivation at early stages of HIV infection followed by declining B cell response within the CNS at advanced infection.
绵羊和山羊的慢病毒病：慢性肺炎、白质脑脊髓炎和关节炎。
DOI：
10.1093/clinids/7.1.89
发表时间：
1985
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Narayan,O;Cork,LC
通讯作者：
Cork,LC
人类和黑猩猩的血脑屏障内人类免疫缺陷病毒抗原和抗体的合成。
DOI：
10.1073/pnas.84.11.3876
发表时间：
1987
影响因子：
11.1
作者：
Goudsmit,J;Epstein,LG;Paul,DA;vanderHelm,HJ;Dawson,GJ;Asher,DM;Yanagihara,R;Wolff,AV;GibbsJr,CJ;Gajdusek,DC
通讯作者：
Gajdusek,DC