Relationship Between Foveal Cone Structure and Visual Acuity Measured With Adaptive Optics Scanning Laser Ophthalmoscopy in Retinal Degeneration.
Relationship Between Foveal Cone Structure and Visual Acuity Measured With Adaptive Optics Scanning Laser Ophthalmoscopy in Retinal Degeneration.
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DOI：
10.1167/iovs.17-23708
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发表时间：
2018-07-02
影响因子：
4.4
通讯作者：
Duncan JL
中科院分区：
文献类型：
--
作者：
Foote KG;Loumou P;Griffin S;Qin J;Ratnam K;Porco TC;Roorda A;Duncan JL
目的：通过测量高阶像差矫正后的视力，评价遗传性视网膜变性（IRD）患者的中央凹功能。应用自适应光学扫描激光检眼镜（AOSLO）对4名健康受试者和15名视网膜病变患者的视锥细胞进行成像。840 nm扫描激光输出“E”光型测量aoslo介导的VA （AOSLO-VA）。由两名独立评分者测量首选视网膜位置的视锥间距，并计算47名年龄相近的健康受试者的视锥低于平均密度的百分比。锥体间距与糖尿病视网膜病变早期治疗研究方案（ETDRS-VA）、AOSLO-VA和中央凹灵敏度测量的最佳校正VA相关。ETDRS-VA与AOSLO-VA显著相关（ρ = 0.79, 95%可信区间[CI] 0.5 ~ 0.9）。锥体间距与AOSLO-VA相关（ρ = 0.54, 95% CI 0.02-0.7），与ETDRS字母读数负相关（ρ = - 0.64, 95% CI - 0.8 - - 0.2）。AOSLO-VA保持≥20/20，直到锥降至低于正常的40.2% （CI 31.1-45.5）。同样，ETDRS-VA保持≥20/20，直到锥体低于正常42.0% （95% CI 36.5-46.1）。锥体间距z评分与中央凹灵敏度呈负相关（ρ = - 0.79, 95% CI为- 0.9 ~ - 0.4），中央凹灵敏度≥35 dB，直到锥体低于平均值43.1% （95% CI为39.3 ~ 46.6）。VA与中央凹锥体间距的相关性较弱，直到锥体减少40%至43%低于正常水平。这一关系表明，VA是衡量中央凹锥体存活的不敏感指标；锥体间距可能是锥体损失的一个更敏感的衡量标准。
To evaluate foveal function in patients with inherited retinal degenerations (IRD) by measuring visual acuity (VA) after correction of higher-order aberrations. Adaptive optics scanning laser ophthalmoscopy (AOSLO) was used to image cones in 4 healthy subjects and 15 patients with IRD. The 840-nm scanning laser delivered an “E” optotype to measure AOSLO-mediated VA (AOSLO-VA). Cone spacing was measured at the preferred retinal locus by two independent graders and the percentage of cones below the average density of 47 age-similar healthy subjects was computed. Cone spacing was correlated with best-corrected VA measured with the Early Treatment of Diabetic Retinopathy Study protocol (ETDRS-VA), AOSLO-VA, and foveal sensitivity. ETDRS-VA significantly correlated with AOSLO-VA (ρ = 0.79, 95% confidence interval [CI] 0.5–0.9). Cone spacing correlated with AOSLO-VA (ρ = 0.54, 95% CI 0.02–0.7), and negatively correlated with ETDRS letters read (ρ = −0.64, 95% CI −0.8 to −0.2). AOSLO-VA remained ≥20/20 until cones decreased to 40.2% (CI 31.1–45.5) below normal. Similarly, ETDRS-VA remained ≥20/20 until cones were 42.0% (95% CI 36.5–46.1) below normal. Cone spacing z scores negatively correlated with foveal sensitivity (ρ = −0.79, 95% CI −0.9 to −0.4) and foveal sensitivity was ≥35 dB until cones were 43.1% (95% CI 39.3–46.6) below average. VA and foveal cone spacing were weakly correlated until cones were reduced by 40% to 43% below normal. The relationship suggests that VA is an insensitive measure of foveal cone survival; cone spacing may be a more sensitive measure of cone loss.
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视网膜图像运动在空间视觉范围内的好处。
影响因子：
1.8
作者：
Ratnam K;Domdei N;Harmening WM;Roorda A
通讯作者：
Roorda A
影响因子：
8.1
作者：
Ratnam, Kavitha;Vastinsalo, Hanna;Duncan, Jacque L.
通讯作者：
Duncan, Jacque L.
影响因子：
4.4
作者：
Duncan, Jacque L.;Zhang, Yuhua;Roorda, Austin
通讯作者：
Roorda, Austin
影响因子：
4.4
作者：
Hood DC;Lin CE;Lazow MA;Locke KG;Zhang X;Birch DG
通讯作者：
Birch DG
DOI：
10.1364/josaa.9.000472
发表时间：
1992-03-01
影响因子：
1.9
作者：
GELLER, AM;SIEVING, PA;GREEN, DG
通讯作者：
GREEN, DG