Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography.
Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography.
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DOI：
10.1167/iovs.08-2936
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发表时间：
2009-05
影响因子：
4.4
通讯作者：
Birch DG
中科院分区：
文献类型：
--
作者：
Hood DC;Lin CE;Lazow MA;Locke KG;Zhang X;Birch DG
为了更好地了解视网膜色素变性（RP）对受体后解剖结构的影响，用频域光学相干断层扫描（fdOCT）测量受体、内核、视网膜神经节细胞（RGC）和视网膜神经纤维层（RNFL）的厚度。在30例RP患者和23例年龄相当的对照受试者中，从水平中线获得FdOCT扫描。导出原始图像，并使用计算机程序辅助的手动分割程序测量感光细胞/RPE、内核、RGC+内部丛状结构和神经纤维层的厚度。还使用环形视乳头周围fdOCT扫描测量了20名对照和25名患者的RNFL厚度。对照的结果与已知解剖结构一致。在RP患者中，光感受器丧失的模式与偏心率是一致的领域收缩特征RP。INL和RGC层测量与正常受试者相当，尽管一些患者显示RGC层略厚。然而，RNFL层厚度明显大于正常值;大多数患者在水平中线扫描和视乳头周围扫描上均显示较厚的RFNL。为了最佳地利用OCT RNFL厚度作为RP患者RGC完整性的衡量标准，需要更好地了解大多数患者增厚的原因。由于RGC层厚度可以用fdOCT测量，因此RGC层厚度可能是RP患者中RGC存在的更直接和有效的指标。
To better understand the effects of retinitis pigmentosa (RP) on post-receptor anatomy, the thicknesses of the receptor, inner nuclear, retinal ganglion cell (RGC), and retinal nerve fiber layers (RNFL) were measured with frequency-domain optical coherence tomography (fdOCT). FdOCT scans were obtained from the horizontal midline in 30 patients with RP and 23 control subjects of comparable age. Raw images were exported and the thicknesses of photoreceptor/RPE, inner nuclear, RGC plus inner plexiform, and nerve fiber layers were measured with a manual segmentation procedure aided by a computer program. The RNFL thickness was also measured in 20 controls and 25 patients using circular peripapillary fdOCT scans. Results from controls were consistent with known anatomy. In patients with RP, the pattern of photoreceptor loss with eccentricity was consistent with the field constriction characteristic of RP. INL and RGC layer measures were comparable to normal subjects, although some patients showed slightly thicker RGC layers. However, RNFL layer thickness was significantly greater than normal; a majority of patients showed a thicker RFNL on both horizontal midline scans and peripapillary scans. To make optimal use of OCT RNFL thickness as a measure of the integrity of RGCs in patients with RP, a better understanding of the causes of the thickening seen in the majority of the patients is needed. As the RGC layer thickness can be measured with fdOCT, RGC layer thickness may turn out to be a more direct and valid indicator of the presence of RGCs in patients with RP.
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