Stress analysis of irradiated human tooth enamel using finite element methods.
Stress analysis of irradiated human tooth enamel using finite element methods.
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DOI：
10.1080/10255842.2017.1383401
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发表时间：
2017-11
影响因子：
1.6
通讯作者：
Walker MP
中科院分区：
文献类型：
--
作者：
Thiagarajan G;Vizcarra B;Bodapudi V;Reed R;Seyedmahmoud R;Wang Y;Gorski JP;Walker MP
本项目的目的是使用有限元方法来确定如何改变弹性模量由于口腔癌治疗辐射改变牙齿中的机械应力分布，并确定是否观察到的失败，在照射牙齿与机械应力的变化。利用MIMICS和3-Matic软件，从磨牙的显微CT切片中构建薄层截面有限元（FE）模型。该模型将牙齿分为三个釉质区域，牙本质-釉质连接部（DEJ）和牙本质。在每个区域中使用纳米压痕确定三个实验组的牙釉质弹性模量，即对照（未辐射）、体外辐射（拔牙后的模拟放射疗法）和体内辐射（口腔癌患者放射疗法后提取）牙齿。生理负荷施加到所有三组（对照，体外和体内）的颊侧和舌侧牙尖区域的牙齿模型。主拉应力和最大剪应力用于比较不同组的结果，因为在以前的研究中已经观察到釉质从下面的牙本质中分层是治疗辐射后牙齿失效的主要原因之一。根据FE数据，我们观察到与对照/未照射牙齿（8.44 ± 1.57 MPa）相比，体内照射牙齿（9.97 ± 1.32 MPa）的内釉质区域内的主拉伸应力增加。我们的模型预测，失败发生在内部釉质/DEJ接口，由于极高的拉伸和最大剪切应力在体内照射的牙齿，这可能是由于放疗的釉质脱层的原因。
The objectives of this project were to use finite element methods to determine how changes in the elastic modulus due to oral cancer therapeutic radiation alter the distribution of mechanical stresses in teeth and to determine if observed failures in irradiated teeth correlate with changes in mechanical stresses. A thin slice section finite element (FE) model was constructed from micro CT sections of a molar tooth using MIMICS and 3-Matic software. This model divides the tooth into three enamel regions, the dentin-enamel junction (DEJ) and dentin. The enamel elastic modulus was determined in each region using nano indentation for three experimental groups namely – control (non-radiated), in vitro irradiated (simulated radiotherapy following tooth extraction) and in vivo irradiated (extracted subsequent to oral cancer patient radiotherapy) teeth. Physiological loads were applied to the tooth models at the buccal and lingual cusp regions for all three groups (control, in vitro and in vivo). The principal tensile stress and the maximum shear stress were used to compare the results from different groups since it has been observed in previous studies that delamination of enamel from the underlying dentin was one of the major reasons for the failure of teeth following therapeutic radiation. From the FE data, we observed an increase in the principal tensile stress within the inner enamel region of in vivo irradiated teeth (9.97 ± 1.32 MPa) as compared to control/non-irradiated teeth (8.44 ± 1.57 MPa). Our model predicts that failure occurs at the inner enamel/DEJ interface due to extremely high tensile and maximum shear stresses in in vivo irradiated teeth which could be a cause of enamel delamination due to radiotherapy.
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影响因子：
4.5
作者：
Xu, Changqi;Reed, Rachel;Gorski, Jeffrey P.;Wang, Yong;Walker, Mary P.
通讯作者：
Walker, Mary P.
影响因子：
3
作者：
Reed, R.;Xu, C.;Liu, Y.;Gorski, J. P.;Wang, Y.;Walker, M. P.
通讯作者：
Walker, M. P.
影响因子：
2.3
作者：
Petrie, Cynthia S.;Walker, Mary P.;Thiagarajan, Ganesh
通讯作者：
Thiagarajan, Ganesh
影响因子：
3.1
作者：
Walker, Mary P.;Williams, Karen B.;Wichman, Brian
通讯作者：
Wichman, Brian
DOI：
10.1115/1.4005694
发表时间：
2012-01-01
影响因子：
1.7
作者：
Maas, Steve A.;Ellis, Benjamin J.;Weiss, Jeffrey A.
通讯作者：
Weiss, Jeffrey A.