Estrogens and Their Receptors in Prostate Cancer: Therapeutic Implications.
Estrogens and Their Receptors in Prostate Cancer: Therapeutic Implications.
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雌激素及其受体在前列腺癌中：治疗意义。
DOI：
10.3389/fonc.2018.00002
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发表时间：
2018
影响因子：
4.7
通讯作者：
Castoria G
中科院分区：
文献类型：
--
作者：
Di Zazzo E;Galasso G;Giovannelli P;Di Donato M;Castoria G
前列腺癌（PC）临床管理的主要挑战是限制肿瘤生长并防止转移扩散。近年来，人们一直在努力寻找新的PC治疗药物，并取得了可喜的进展。已经设计了药理学方法来实现PC治疗的益处，并避免由施用拮抗剂或激动剂或新药引起的负面副作用。尽管如此，目前可用的治疗经常诱导抗性和PC进展到去势抵抗的形式，这可能是由雄激素受体再激活和/或突变，或信号通路紊乱引起的。临床前和临床研究结果也表明，其他核受体经常改变PC。在这篇综述中，我们专注于雌二醇/雌二醇受体（ER）轴，控制PC的生长和进展的作用。选择性靶向ER亚型（α或β）可能是限制前列腺癌细胞生长和扩散的一种有吸引力的方法。
A major challenge in clinical management of prostate cancer (PC) is to limit tumor growth and prevent metastatic spreading. Considerable efforts have been made to discover new compounds for PC therapy and recent years have seen promising progress in this field. Pharmacological approaches have been designed to achieve benefits in PC treatment and avoid the negative side effects resulting from administration of antagonists or agonists or new drugs. Nonetheless, the currently available therapies frequently induce resistance and PC progresses toward castration-resistant forms that can be caused by the androgen receptor reactivation and/or mutations, or derangement of signaling pathways. Preclinical and clinical findings have also shown that other nuclear receptors are frequently altered in PC. In this review, we focus on the role of estradiol/estradiol receptor (ER) axis, which controls PC growth and progression. Selective targeting of ER subtypes (α or β) may be an attractive way to limit the growth and spreading of prostatic cancer cells.
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影响因子：
9
作者：
Castoria G;Giovannelli P;Di Donato M;Ciociola A;Hayashi R;Bernal F;Appella E;Auricchio F;Migliaccio A
通讯作者：
Migliaccio A
DOI：
10.1016/j.jsbmb.2009.10.015
发表时间：
2010-02-28
影响因子：
4.1
作者：
Ellem, Stuart J.;Risbridger, Gail P.
通讯作者：
Risbridger, Gail P.
影响因子：
7
作者：
Di Donato M;Cernera G;Auricchio F;Migliaccio A;Castoria G
通讯作者：
Castoria G
影响因子：
3.8
作者：
Fujimura T;Takahashi S;Kume H;Urano T;Takayama K;Yamada Y;Suzuki M;Fukuhara H;Nakagawa T;Inoue S;Homma Y
通讯作者：
Homma Y
Bisphenol A通过EGFR/ERK/p53信号通路激活诱导原发性和前列腺癌细胞中的细胞周期停滞。
影响因子：
--
作者：
Bilancio A;Bontempo P;Di Donato M;Conte M;Giovannelli P;Altucci L;Migliaccio A;Castoria G
通讯作者：
Castoria G