Cross-talk between androgen receptor and nerve growth factor receptor in prostate cancer cells: implications for a new therapeutic approach.
Cross-talk between androgen receptor and nerve growth factor receptor in prostate cancer cells: implications for a new therapeutic approach.
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DOI：
10.1038/s41420-017-0024-3
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发表时间：
2018-12
影响因子：
7
通讯作者：
Castoria G
中科院分区：
文献类型：
--
作者：
Di Donato M;Cernera G;Auricchio F;Migliaccio A;Castoria G
前列腺癌（PC）是西方社会男性癌症死亡的第二大原因。然而，目前PC的治疗仍然不令人满意，PC经常进展为去势抵抗表型。临床前和临床研究旨在研究PC进展1的分子基础。神经生长因子（NGF）属于哺乳动物神经营养因子家族的生长因子，控制生存，分化和神经突生长。神经营养因子还作用于许多不同的细胞类型，并且在许多肿瘤（包括PC）中发现其信号通路的失调。两类细胞表面受体，称为Trks（TrkA、TrkB、TrkC）的酪氨酸受体激酶家族和p75NTR受体，介导神经营养因子2的作用。PC经常合成大量的NGF，这反过来又刺激TrkA 3。因此，TrkA可能是一个有前途的目标在PC therapeutic.In这份报告中，我们表明，雄激素和神经生长因子都诱导雄激素受体（AR）和TrkA在前列腺癌衍生的LNCaP细胞之间的相互串扰。这种串扰使人想起在神经元PC 12细胞4中观察到的串扰，最终生物学结果存在显著差异，一方面导致PC细胞的增殖和迁移，另一方面导致PC 12细胞的分化。
Prostate cancer (PC) is the second leading cause of cancer death in men in Western society. Current therapies for PC remain, however, unsatisfactory and PC frequently progresses toward a castrate-resistant phenotype. Preclinical and clinical studies are aimed at investigating the molecular basis for PC progression 1. Nerve growth factor (NGF) belongs to the mammalian neurotrophin family of growth factors that control survival, differentiation, and neurite outgrowth. Neurotrophins also act on many different cell types, and deregulation of their signaling pathways is found in a number of tumors, including PC. Two classes of cell surface receptors, a family of tyrosine receptor kinases called Trks (TrkA, TrkB, TrkC) and the p75NTR receptor, mediate the effects of neurotrophins 2. PC frequently synthesizes large amounts of NGF, which in turns stimulates TrkA 3. Thus, TrkA might represent a promising target in PC therapies.In this report, we show that androgens and NGF both induce a reciprocal cross-talk between androgen receptor (AR) and TrkA in prostate cancer-derived LNCaP cells. Such cross-talk is reminiscent of that observed in neuronal PC12 cells 4, with significant differences in the final biological outcome, resulting on one hand in proliferation and migration of PC cells, and differentiation of PC12 cells on the other.
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影响因子：
9
作者：
Castoria G;Giovannelli P;Di Donato M;Ciociola A;Hayashi R;Bernal F;Appella E;Auricchio F;Migliaccio A
通讯作者：
Migliaccio A
影响因子：
3.3
作者：
Di Donato M;Bilancio A;D'Amato L;Claudiani P;Oliviero MA;Barone MV;Auricchio A;Appella E;Migliaccio A;Auricchio F;Castoria G
通讯作者：
Castoria G
影响因子：
6.4
作者：
Kruettgen, Alex;Schneider, Imke;Weis, Joachim
通讯作者：
Weis, Joachim
影响因子：
--
作者：
Sortino, MA;Condorelli, F;Canonico, PL
通讯作者：
Canonico, PL
影响因子：
12.8
作者：
Jung, Eun Joo;Kim, Choong Won;Kim, Deok Ryong
通讯作者：
Kim, Deok Ryong