Functional diversity of fibroblast growth factors in bone formation.
Functional diversity of fibroblast growth factors in bone formation.
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DOI：
10.1155/2015/729352
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发表时间：
2015
影响因子：
2.8
通讯作者：
Yoshiko Y
中科院分区：
文献类型：
--
作者：
Takei Y;Minamizaki T;Yoshiko Y
成纤维细胞生长因子 (FGF) 信号在骨形成中的功能意义已通过遗传功能丧失和功能获得方法得到证实。 FGF 由 22 个家族成员组成，分为三个亚家族：典型亚族、激素样亚族和细胞内亚族。前两个亚家族通过 FGF 受体 (FGFR) 激活其信号通路。目前，细胞内 FGF 似乎主要参与神经系统。 FGF2等经典FGF在骨形成中发挥着重要作用，在转录和转录后水平上对FGF和FGFR进行精确的时空控制可能会导致FGF在骨形成过程中的功能多样性。最近，包括我们在内的几个研究小组已经表明，FGF23（激素样 FGF 亚家族的成员）主要在骨细胞/成骨细胞中表达。这种多肽通过抑制肾脏磷酸盐重吸收和维生素 D3 活化来降低血清磷酸盐水平，从而导致骨矿化缺陷。因此，FGF 参与骨形成的正向和负向调节。在这篇综述中，我们重点关注 FGF 在骨形成中的相互作用及其局部效应和全身效应。
The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. FGFs, comprising 22 family members, are classified into three subfamilies: canonical, hormone-like, and intracellular. The former two subfamilies activate their signaling pathways through FGF receptors (FGFRs). Currently, intracellular FGFs appear to be primarily involved in the nervous system. Canonical FGFs such as FGF2 play significant roles in bone formation, and precise spatiotemporal control of FGFs and FGFRs at the transcriptional and posttranscriptional levels may allow for the functional diversity of FGFs during bone formation. Recently, several research groups, including ours, have shown that FGF23, a member of the hormone-like FGF subfamily, is primarily expressed in osteocytes/osteoblasts. This polypeptide decreases serum phosphate levels by inhibiting renal phosphate reabsorption and vitamin D3 activation, resulting in mineralization defects in the bone. Thus, FGFs are involved in the positive and negative regulation of bone formation. In this review, we focus on the reciprocal roles of FGFs in bone formation in relation to their local versus systemic effects.
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影响因子：
3.7
作者：
Arai-Nunota N;Mizobuchi M;Ogata H;Yamazaki-Nakazawa A;Kumata C;Kondo F;Hosaka N;Koiwa F;Kinugasa E;Shibata T;Akizawa T
通讯作者：
Akizawa T
影响因子：
6.2
作者：
Dunstan, CR;Boyce, R;Mundy, GR
通讯作者：
Mundy, GR
DOI：
10.1152/ajprenal.90742.2008
发表时间：
2009-08-01
影响因子：
4.2
作者：
Gattineni, Jyothsna;Bates, Carlton;Baum, Michel
通讯作者：
Baum, Michel
影响因子：
4.8
作者：
Collet, C.;Schiltz, C.;de Vernejoul, M. -C.
通讯作者：
de Vernejoul, M. -C.
影响因子：
6.2
作者：
Aguirre, J. Ignacio;Leal, Martha E.;Wronski, Thomas J.
通讯作者：
Wronski, Thomas J.