Engineering mammary gland in vitro models for cancer diagnostics and therapy.
Engineering mammary gland in vitro models for cancer diagnostics and therapy.
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用于癌症诊断和治疗的体外乳腺模型。
DOI：
10.1021/mp500121c
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发表时间：
2014
影响因子：
4.9
通讯作者：
Campbell JJ
中科院分区：
文献类型：
--
作者：
Campbell JJ
乳腺癌是一种复杂的疾病，具有许多不同的亚型，根据组织学特征和分子特征进行识别。很难预测癌症对治疗的反应，这导致许多妇女接受不必要或不适当的治疗。材料科学和组织工程学的进步正在引领复杂的体外3D乳腺组织模型的发展，这将增加我们对正常发育和肿瘤发生机制的理解。最终，支持原代组织培养的平台可以很容易地适应形成个性化医疗的高通量药物筛选工具。本文将总结乳腺表型的控制withininininVitro3D环境中，在乳腺发育和干细胞和祖细胞控制的肿瘤发生的详细分析的背景下。
Breast cancer is a complex disease with many distinct subtypes being recognized on the basis of histological features and molecular signatures. It is difficult to predict how cancers will respond to therapy, which results in many women receiving unnecessary or inappropriate treatment. Advances in materials science and tissue engineering are leading the development of complexin vitro3D breast tissue models that will increase our understanding of normal development and tumorigenic mechanisms. Ultimately, platforms that support primary tissue culture could readily be adapted to form high-throughput drug screening tools for personalized medicine. This review will summarize the control of mammary gland phenotype withinin vitro3D environments, in the context of a detailed analysis of mammary gland development and stem and progenitor cell controlled tumorigenesis.
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影响因子：
11.2
作者：
Liu S;Ginestier C;Ou SJ;Clouthier SG;Patel SH;Monville F;Korkaya H;Heath A;Dutcher J;Kleer CG;Jung Y;Dontu G;Taichman R;Wicha MS
通讯作者：
Wicha MS
DOI：
10.1073/pnas.0401064101
发表时间：
2004-04-06
影响因子：
11.1
作者：
Kuperwasser, C;Chavarria, T;Weinberg, RA
通讯作者：
Weinberg, RA
影响因子：
21.3
作者：
Taddei, Ilaria;Deugnier, Marie-Ange;Glukhova, Marina A.
通讯作者：
Glukhova, Marina A.
影响因子：
4.1
作者：
Willard, James J.;Drexler, Jason W.;Powell, Heather M.
通讯作者：
Powell, Heather M.
DOI：
10.1186/bcr3493
发表时间：
2013-10-01
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Eccles SA;Aboagye EO;Ali S;Anderson AS;Armes J;Berditchevski F;Blaydes JP;Brennan K;Brown NJ;Bryant HE;Bundred NJ;Burchell JM;Campbell AM;Carroll JS;Clarke RB;Coles CE;Cook GJ;Cox A;Curtin NJ;Dekker LV;Silva Idos S;Duffy SW;Easton DF;Eccles DM;Edwards DR;Edwards J;Evans D;Fenlon DF;Flanagan JM;Foster C;Gallagher WM;Garcia-Closas M;Gee JM;Gescher AJ;Goh V;Groves AM;Harvey AJ;Harvie M;Hennessy BT;Hiscox S;Holen I;Howell SJ;Howell A;Hubbard G;Hulbert-Williams N;Hunter MS;Jasani B;Jones LJ;Key TJ;Kirwan CC;Kong A;Kunkler IH;Langdon SP;Leach MO;Mann DJ;Marshall JF;Martin L;Martin SG;Macdougall JE;Miles DW;Miller WR;Morris JR;Moss SM;Mullan P;Natrajan R;O'Connor JP;O'Connor R;Palmieri C;Pharoah PD;Rakha EA;Reed E;Robinson SP;Sahai E;Saxton JM;Schmid P;Smalley MJ;Speirs V;Stein R;Stingl J;Streuli CH;Tutt AN;Velikova G;Walker RA;Watson CJ;Williams KJ;Young LS;Thompson AM
通讯作者：
Thompson AM