Paradoxical Roles of Desmosomal Components in Head and Neck Cancer.
Paradoxical Roles of Desmosomal Components in Head and Neck Cancer.
复制标题
桥粒成分在头颈癌中的矛盾作用。
DOI：
10.3390/biom11060914
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发表时间：
2021-06-20
期刊：
影响因子：
5.5
通讯作者：
Fang WK
中科院分区：
文献类型：
--
作者：
Liu YQ;Zou HY;Xie JJ;Fang WK
桥粒是一种细胞间黏附复合体，参与上皮细胞病理生理学的各个方面，包括组织内稳态、形态发生和疾病发展。最近的研究报道，各种桥粒成分的异常表达与肿瘤的进展和生存不良有关。此外，桥粒已被证明是一个信号平台，调节癌细胞的增殖、侵袭、迁移、形态发生和凋亡。头颈部癌的发生和发展伴随着桥粒成分的异常表达和桥粒结构的丢失。然而，桥粒成分在HNC进展中的作用仍然存在争议。本综述旨在综述桥粒成分在肿瘤抑制和促进中的矛盾作用的最新研究进展。它为HNC的诊断和治疗的发展提供了有价值的见解。
Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development. Recent studies have reported that the abnormal expression of various desmosomal components correlates with tumor progression and poor survival. In addition, desmosomes have been shown to act as a signaling platform to regulate the proliferation, invasion, migration, morphogenesis, and apoptosis of cancer cells. The occurrence and progression of head and neck cancer (HNC) is accompanied by abnormal expression of desmosomal components and loss of desmosome structure. However, the role of desmosomal components in the progression of HNC remains controversial. This review aims to provide an overview of recent developments showing the paradoxical roles of desmosomal components in tumor suppression and promotion. It offers valuable insights for HNC diagnosis and therapeutics development.
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影响因子：
--
作者：
Li Y;Liu N;Huang D;Zhang Z;Peng Z;Duan C;Tang X;Tan G;Yan G;Mei W;Tang F
通讯作者：
Tang F
影响因子：
10.9
作者：
Charap AJ;Enokida T;Brody R;Sfakianos J;Miles B;Bhardwaj N;Horowitz A
通讯作者：
Horowitz A
影响因子：
11.2
作者：
Beyer I;van Rensburg R;Strauss R;Li Z;Wang H;Persson J;Yumul R;Feng Q;Song H;Bartek J;Fender P;Lieber A
通讯作者：
Lieber A
影响因子：
4
作者：
Aktary, Zackie;Kulak, Stephen;Pasdar, Manijeh
通讯作者：
Pasdar, Manijeh
影响因子：
8
作者：
Chen, Y-J;Chang, J. T.;Cheng, A-J
通讯作者：
Cheng, A-J