Landscape of natural killer cell activity in head and neck squamous cell carcinoma.
Landscape of natural killer cell activity in head and neck squamous cell carcinoma.
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DOI：
10.1136/jitc-2020-001523
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发表时间：
2020-12
影响因子：
10.9
通讯作者：
Horowitz A
中科院分区：
文献类型：
--
作者：
Charap AJ;Enokida T;Brody R;Sfakianos J;Miles B;Bhardwaj N;Horowitz A
头颈鳞状细胞癌 (HNSCC) 包括一系列源自上呼吸消化道上皮的癌症，由于该疾病的死亡率、发病率和复发倾向，在全世界范围内造成了重大的疾病负担。复发性和/或转移性 (R/M-HNSCC) 情况下的 HNSCC 预后尤其差，有效的治疗方案越来越依赖于调节 T 细胞抗肿瘤反应。尽管如此，免疫疗法的反应率普遍较低，促使人们探索将其他效应细胞纳入肿瘤微环境的新策略。在过去的十年中，利用自然杀伤 (NK) 细胞强大的先天抗肿瘤功能来治疗实体瘤（包括头颈鳞状细胞癌）取得了重要进展。 NK 细胞是混合型先天适应性效应细胞，除了启动适应性抗肿瘤免疫反应外，还能够直接消除肿瘤细胞。在 HNSCC 中，NK 细胞对于肿瘤监测和控制非常重要，NK 细胞浸润一再与良好的预后相关。然而，HNSCC 浸润的 NK 细胞很容易受到肿瘤采用的一系列免疫逃避策略的影响，必须克服这些策略才能充分发挥 NK 细胞的抗肿瘤潜力。我们相信，基于对 NK 细胞激活机制的基本生物学理解的概念框架可以改善 HNSCC 的治疗，部分方法是选择最有可能对基于 NK 细胞的免疫疗法产生反应的患者。在此，我们回顾了 NK 细胞在 HNSCC 中的活性，特别关注环境和遗传决定因素对 NK 细胞抗肿瘤功能的作用。此外，我们还探讨了 NK 细胞是 HNSCC 现有和新兴疗法疗效的关键决定因素的证据。
Head and neck squamous cell carcinoma (HNSCC) encompasses a set of cancers arising from the epithelia of the upper aerodigestive tract, accounting for a significant burden of disease worldwide due to the disease’s mortality, morbidity, and predilection for recurrence. Prognosis of HNSCC in the recurrent and/or metastatic (R/M-HNSCC) setting is especially poor and effective treatment options increasingly rely on modulating T-cell antitumor responses. Still, immunotherapy response rates are generally low, prompting the exploration of novel strategies that incorporate other effector cells within the tumor microenvironment. Within the last decade, important advances have been made leveraging the powerful innate antitumor function of natural killer (NK) cells to treat solid tumors, including head and neck squamous cell carcinoma. NK cells are hybrid innate-adaptive effector cells capable of directly eliminating tumor cells in addition to initiating adaptive antitumor immune responses. In the setting of HNSCC, NK cells are important for tumor surveillance and control, and NK cell infiltration has repeatedly been associated with a favorable prognosis. Yet, HNSCC-infiltrating NK cells are susceptible to an array of immune evasion strategies employed by tumors that must be overcome to fully realize the antitumor potential of NK cells. We believe that a conceptual framework informed by the basic biological understanding of the mechanisms underlying NK cell activation can improve treatment of HNSCC, in part by selecting for patients most likely to respond to NK cell-based immunotherapy. Herein, we review the activity of NK cells in HNSCC, paying special attention to the role of environmental and genetic determinants of NK cell antitumor function. Moreover, we explore the evidence that NK cells are a crucial determinant of the efficacy of both established and emerging treatments for HNSCC.
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影响因子：
4.6
作者：
Albers AE;Qian X;Kaufmann AM;Coordes A
通讯作者：
Coordes A
影响因子：
5.7
作者：
Bertino EM;McMichael EL;Mo X;Trikha P;Davis M;Paul B;Grever M;Carson WE;Otterson GA
通讯作者：
Otterson GA
DOI：
10.1126/science.aao0505
发表时间：
2018-03-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ferrari de Andrade L;Tay RE;Pan D;Luoma AM;Ito Y;Badrinath S;Tsoucas D;Franz B;May KF Jr;Harvey CJ;Kobold S;Pyrdol JW;Yoon C;Yuan GC;Hodi FS;Dranoff G;Wucherpfennig KW
通讯作者：
Wucherpfennig KW
DOI：
10.1084/jem.187.5.813
发表时间：
1998-03-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Borrego F;Ulbrecht M;Weiss EH;Coligan JE;Brooks AG
通讯作者：
Brooks AG
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T