Transcranial Focal Electrical Stimulation Modifies Biogenic Amines' Alterations Induced by 6-Hydroxydopamine in Rat Brain.
Transcranial Focal Electrical Stimulation Modifies Biogenic Amines' Alterations Induced by 6-Hydroxydopamine in Rat Brain.
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DOI：
10.3390/ph14080706
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发表时间：
2021-07-21
期刊：
影响因子：
--
通讯作者：
Rocha L
中科院分区：
文献类型：
--
作者：
Santana-Gómez CE;Pérez-Pérez D;Fonseca-Barriendos D;Arias-Carrión O;Besio W;Rocha L
经颅局灶刺激（TFS）是一种具有神经保护作用的非侵入性神经调节策略。另一方面，6-羟基多巴胺 (6-OHDA) 会诱导黑质纹状体系统的神经变性，从而对多巴胺能、血清素能和组胺能系统产生修饰。本研究旨在测试重复应用 TFS 是否可以避免纹状体内注射 6-OHDA 引起的生物胺变化。实验旨在测定注射 6-OHDA 并连续 21 天每天接受 TFS 的动物大脑中多巴胺、血清素和组胺的组织含量。评估了 6-OHDA 注射侧的大脑皮层、海马、杏仁核和纹状体、同侧和对侧的生物胺的组织含量。将获得的结果与使用 6-OHDA、单独 TFS 和假手术组的动物进行比较。目前的研究表明，TFS并没有避免纹状体中多巴胺组织含量的变化。然而，TFS 能够避免 6-OHDA 在所评估的不同脑区的多巴胺、血清素和组胺组织含量中引起的一些变化。有趣的是，单独的 TFS 并没有引起所评估的不同大脑区域的显着变化。本研究表明，重复 TFS 避免了 6-OHDA 引起的生物胺变化。 TFS 可以代表一种新的治疗策略，以避免 6-OHDA 引起的神经毒性。
Transcranial focal stimulation (TFS) is a non-invasive neuromodulation strategy with neuroprotective effects. On the other hand, 6-hidroxidopamine (6-OHDA) induces neurodegeneration of the nigrostriatal system producing modifications in the dopaminergic, serotoninergic, and histaminergic systems. The present study was conducted to test whether repetitive application of TFS avoids the biogenic amines’ changes induced by the intrastriatal injection of 6-OHDA. Experiments were designed to determine the tissue content of dopamine, serotonin, and histamine in the brain of animals injected with 6-OHDA and then receiving daily TFS for 21 days. Tissue content of biogenic amines was evaluated in the cerebral cortex, hippocampus, amygdala, and striatum, ipsi- and contralateral to the side of 6-OHDA injection. Results obtained were compared to animals with 6-OHDA, TFS alone, and a Sham group. The present study revealed that TFS did not avoid the changes in the tissue content of dopamine in striatum. However, TFS was able to avoid several of the changes induced by 6-OHDA in the tissue content of dopamine, serotonin, and histamine in the different brain areas evaluated. Interestingly, TFS alone did not induce significant changes in the different brain areas evaluated. The present study showed that repetitive TFS avoids the biogenic amines’ changes induced by 6-OHDA. TFS can represent a new therapeutic strategy to avoid the neurotoxicity induced by 6-OHDA.
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