HbA1c and the Prediction of Type 2 Diabetes in Children and Adults.
HbA1c and the Prediction of Type 2 Diabetes in Children and Adults.
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DOI：
10.2337/dc16-1358
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发表时间：
2017-01
期刊：
影响因子：
16.2
通讯作者：
Sinha M
中科院分区：
文献类型：
--
作者：
Vijayakumar P;Nelson RG;Hanson RL;Knowler WC;Sinha M
验证糖化血红蛋白（HbA 1c）在评估儿童2型糖尿病风险方面的长期数据有限。在一项对美国印第安人的纵向研究中，测量了HbA 1c、空腹血糖（FPG）和2小时负荷后血糖（2 hPG）浓度，以确定其在预测糖尿病事件中的效用，所有这些都被认为是该人群中的2型糖尿病。在2，095名10-19岁无糖尿病儿童（监测至39岁）和2，005名20-39岁成人（监测至59岁）中确定了新发糖尿病（FPG ≥126 mg/dL [7.0 mmol/L]、2 hPG ≥200 mg/dL [11.1 mmol/L]、HbA 1c ≥6.5% [8 mmol/mol]或临床诊断）。比较HbA 1c、FPG和2 hPG在预测10年内糖尿病的受试者工作特征（ROC）曲线下面积。在对最初未患糖尿病的儿童和青少年的长期随访中，HbA 1c ≥5.7%的儿童和青少年随后患糖尿病的发生率是HbA 1c ≤ 5.3%的儿童和青少年的4倍（男孩）和7倍以上（女孩）-比相同HbA 1c类别的成人发生率更高。ROC分析显示，HbA 1c、FPG和2 hPG在识别儿童和青少年后来患糖尿病的敏感性和特异性方面无显著差异。HbA 1c是儿童糖尿病风险的有用预测因子，可用于识别具有与FPG和2 hPG相同预测价值的其他2型糖尿病风险因素的儿童的前驱糖尿病。
Long-term data validating glycated hemoglobin (HbA1c) in assessing the risk of type 2 diabetes in children are limited. HbA1c, fasting plasma glucose (FPG), and 2-h postload plasma glucose (2hPG) concentrations were measured in a longitudinal study of American Indians to determine their utility in predicting incident diabetes, all of which is thought to be type 2 in this population. Incident diabetes (FPG ≥126 mg/dL [7.0 mmol/L], 2hPG ≥200 mg/dL [11.1 mmol/L], HbA1c ≥6.5% [8 mmol/mol], or clinical diagnosis) was determined in 2,095 children without diabetes ages 10–19 years monitored through age 39, and in 2,005 adults ages 20–39 monitored through age 59. Areas under the receiver operating characteristic (ROC) curve for HbA1c, FPG, and 2hPG in predicting diabetes within 10 years were compared. During long-term follow-up of children and adolescents who did not initially have diabetes, the incidence rate of subsequent diabetes was fourfold (in boys) as high and more than sevenfold (in girls) as high in those with HbA1c ≥5.7% as in those with HbA1c ≤5.3%—greater rate ratios than experienced by adults in the same HbA1c categories. Analyses of ROCs revealed no significant differences between HbA1c, FPG, and 2hPG in sensitivity and specificity for identifying children and adolescents who later developed diabetes. HbA1c is a useful predictor of diabetes risk in children and can be used to identify prediabetes in children with other type 2 diabetes risk factors with the same predictive value as FPG and 2hPG.
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影响因子：
16.2
作者：
通讯作者：
--
影响因子：
5.1
作者：
Kershnar, Ann K.;Daniels, Stephen R.;Rodriguez, Beatriz L.
通讯作者：
Rodriguez, Beatriz L.
影响因子：
2
作者：
Pencina, MJ;D'Agostino, RB
通讯作者：
D'Agostino, RB
影响因子：
3.4
作者：
Lippi, Giuseppe;Targher, Giovanni
通讯作者：
Targher, Giovanni
影响因子：
16.2
作者：
Krakoff, J;Kobes, S;Knowler, WC
通讯作者：
Knowler, WC