Cutaneous Squamous Cell Carcinomas in Organ Transplant Recipients.
Cutaneous Squamous Cell Carcinomas in Organ Transplant Recipients.
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DOI：
10.3390/jcm4061229
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发表时间：
2015-06-03
影响因子：
3.9
通讯作者：
Tyring SK
中科院分区：
文献类型：
--
作者：
Chockalingam R;Downing C;Tyring SK
非黑色素瘤皮肤癌是器官移植后发病的主要原因。鳞状细胞癌（SCC）是该人群中最常见的皮肤恶性肿瘤，与一般人群相比，器官移植受者的发病率高65-100倍。近年来，人乳头瘤病毒（HPV）的β属已涉及移植后SCC的发病机制。致癌的潜在机制归因于HPV的E6和E7蛋白。与其他免疫抑制剂相比，特定的免疫抑制药物，如钙调磷酸酶抑制剂和硫唑嘌呤，与移植后SCC的发生率较高相关。与其他免疫抑制剂相比，mTOR抑制剂和吗替麦考酚酯与移植后非黑色素瘤皮肤癌的发生风险降低有关。因此，它们可能是器官移植受者理想的免疫抑制药物。移植后SCC的治疗选择包括手术切除、莫氏显微手术、全身性维甲酸治疗、辅助局部治疗、电干燥和刮除以及放射治疗。本综述将讨论移植后SCC的流行病学、危险因素和管理选择。此外，将讨论β-HPV介导的致癌作用的潜在机制。
Non-melanoma skin cancers represent a major cause of morbidity after organ transplantation. Squamous cell carcinomas (SCC) are the most common cutaneous malignancies seen in this population, with a 65–100 fold greater incidence in organ transplant recipients compared to the general population. In recent years, human papillomaviruses (HPV) of the beta genus have been implicated in the pathogenesis of post-transplant SCCs. The underlying mechanism of carcinogenesis has been attributed to the E6 and E7 proteins of HPV. Specific immunosuppressive medications, such as the calcineurin inhibitors and azathioprine, are associated with a higher incidence of post-transplant SCCs compared to other immunosuppressive agents. Compared to other immunosuppressives, mTOR inhibitors and mycophenolate mofetil have been associated with a decreased risk of developing post-transplant non-melanoma skin cancers. As a result, they may represent ideal immunosuppressive medications in organ transplant recipients. Treatment options for post-transplant SCCs include surgical excision, Mohs micrographic surgery, systemic retinoid therapy, adjunct topical therapy, electrodessication and curettage, and radiation therapy. This review will discuss the epidemiology, risk factors, and management options of post-transplant SCCs. In addition, the underlying mechanisms of beta-HPV mediated carcinogenesis will be discussed.
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影响因子：
11.1
作者：
Doorbar, John;Egawa, Nagayasu;Griffin, Heather;Kranjec, Christian;Murakami, Isao
通讯作者：
Murakami, Isao
影响因子：
4.8
作者：
Gabet, Anne-Sophie;Accardi, Rosita;Tommasino, Massimo
通讯作者：
Tommasino, Massimo
影响因子：
3.7
作者：
Howley, Peter M.;Pfister, Herbert J.
通讯作者：
Pfister, Herbert J.
影响因子：
5.4
作者：
Caldeira, S;Zehbe, I;Tommasino, M
通讯作者：
Tommasino, M
影响因子：
10.3
作者：
Lindelöf, B;Sigurgeirsson, B;Stern, RS
通讯作者：
Stern, RS