Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.
Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.
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DOI：
10.1371/journal.pone.0105561
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Huang YH
中科院分区：
文献类型：
--
作者：
Xu X;Jaeger ER;Wang X;Lagler-Ferrez E;Batalov S;Mathis NL;Wiltshire T;Walker JR;Cooke MP;Sauer K;Huang YH
Chemokines promote T cell migration by transmitting signals that induce T cell polarization and integrin activation and adhesion. Mst1 kinase is a key signal mediator required for both of these processes; however, its molecular mechanism remains unclear. Here, we present a mouse model in which Mst1 function is disrupted by a hypomorphic mutation. Microscopic analysis of Mst1-deficient CD4 T cells revealed a necessary role for Mst1 in controlling the localization and activity of Myosin IIa, a molecular motor that moves along actin filaments. Using affinity specific LFA-1 antibodies, we identified a requirement for Myosin IIa-dependent contraction in the precise spatial distribution of low and higher affinity LFA-1 on the membrane of migrating T cells. Mst1 deficiency or Myosin inhibition resulted in multipolar cells, difficulties in uropod detachment and mis-localization of low affinity LFA-1. Thus, Mst1 regulates Myosin IIa dynamics to organize high and low affinity LFA-1 to the anterior and posterior membrane during T cell migration.
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影响因子：
3.7
作者：
Crequer A;Picard C;Patin E;D'Amico A;Abhyankar A;Munzer M;Debré M;Zhang SY;de Saint-Basile G;Fischer A;Abel L;Orth G;Casanova JL;Jouanguy E
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Jouanguy E
影响因子：
30.5
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影响因子：
20.3
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影响因子：
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作者：
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通讯作者：
Sixt, Michael
DOI：
10.1084/jem.20111692
发表时间：
2012-04-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mou F;Praskova M;Xia F;Van Buren D;Hock H;Avruch J;Zhou D
通讯作者：
Zhou D