Treatment outcome of tuberculosis patients at Gondar University Teaching Hospital, Northwest Ethiopia. A five--year retrospective study.
Treatment outcome of tuberculosis patients at Gondar University Teaching Hospital, Northwest Ethiopia. A five--year retrospective study.
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DOI：
10.1186/1471-2458-9-371
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发表时间：
2009-10-04
影响因子：
4.5
通讯作者：
Sack U
中科院分区：
文献类型：
--
作者：
Tessema B;Muche A;Bekele A;Reissig D;Emmrich F;Sack U
贡达尔大学教学医院于2000年开始实施标准化的结核病预防和控制方案，其中包括短期直接观察治疗。根据世界卫生组织（WHO）的建议，治疗结果是结核病控制项目的重要指标。本研究调查了埃塞俄比亚西北部贡达尔大学教学医院结核病治疗的结果。我们分析了从2003年9月到2008年5月在贡达大学教学医院登记的4000例肺结核患者的记录。根据国家结核病控制项目指南对治疗结果和结核病类型进行分类。采用Logistic回归模型进行多因素分析，以分析治疗结果和潜在的预测变量之间的关系。肺外结核1133例（28.3%），涂阴肺结核2196例（54.9%），涂阳肺结核671例（16.8%）。在所有患者中，治疗结果分类为1181例（29.5%）成功治疗，730例（18.3%）失访，403例（10.1%）死亡，6例（0.2%）治疗失败，1680例（42.0%）患者转出。男性比女性更有可能经历死亡或违约，老年人比年轻人更有可能死亡。违约率的比例逐年上升，由97家（9. 2%）上升至228家（42. 9%）。女性、15-24岁年龄组、涂阳肺结核和城市居民的治疗成功率较高。肺结核病人的治疗成功率较低（29.5%）。高比例的患者死亡（10.1%）或违约（18.3%），这是一个严重的公共卫生问题，需要紧急解决。
In Gondar University Teaching Hospital standardized tuberculosis prevention and control programme, incorporating Directly Observed Treatment, Short Course (DOTS) started in 2000. According to the proposal of World Health Organization (WHO), treatment outcome is an important indicator of tuberculosis control programs. This study investigated the outcome of tuberculosis treatment at Gondar University Teaching Hospital in Northwest Ethiopia. We analyzed the records of 4000 tuberculosis patients registered at Gondar University Teaching Hospital from September 2003 to May 2008. Treatment outcome and tuberculosis type were categorized according to the national tuberculosis control program guideline. Multivariate analysis using logistic regression model was used to analyse the association between treatment outcome and potential predictor variables. From the total of 4000 patients, tuberculosis type was categorized as extrapulmonary in 1133 (28.3%), smear negative pulmonary tuberculosis in 2196 (54.9%) and smear positive pulmonary tuberculosis in 671 (16.8%) cases. Of all patients, treatment outcome was classified as successfully treated in 1181(29.5%), defaulted in 730 (18.3%), died in 403 (10.1%), treatment failed in six (0.2%) and transferred out in 1680 (42.0%) patients. Males had the trend to be more likely to experience death or default than females, and the elderly were more likely to die than younger. The proportion of default rate was increased across the years from 97(9.2%) to 228(42.9%). Being female, age group 15-24 years, smear positive pulmonary tuberculosis and being urban resident were associated with higher treatment success rate. The treatment success rate of tuberculosis patients was unsatisfactorily low (29.5%). A high proportion of patients died (10.1%) or defaulted (18.3%), which is a serious public health concern that needs to be addressed urgently.
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影响因子：
5.4
作者：
Demissie, M;Getahun, H;Lindtjorn, B
通讯作者：
Lindtjorn, B
影响因子：
6.4
作者：
Dye, C;Espinal, MA;Williams, BG
通讯作者：
Williams, BG
DOI：
10.1016/0962-8479(93)90053-z
发表时间：
1993-08-01
期刊：
TUBERCLE AND LUNG DISEASE
影响因子：
--
作者：
JIN, BW;KIM, SC;SHIMAO, T
通讯作者：
SHIMAO, T
DOI：
10.1164/ajrccm/147.5.1311
发表时间：
1993-05-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
SUMARTOJO, E
通讯作者：
SUMARTOJO, E
影响因子：
158.5
作者：
WEIS, SE;SLOCUM, PC;FORESMAN, BH
通讯作者：
FORESMAN, BH