The association between type 2 diabetes mellitus and women cancer: the epidemiological evidences and putative mechanisms.
The association between type 2 diabetes mellitus and women cancer: the epidemiological evidences and putative mechanisms.
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DOI：
10.1155/2015/920618
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发表时间：
2015
影响因子：
--
通讯作者：
Ku BJ
中科院分区：
文献类型：
--
作者：
Joung KH;Jeong JW;Ku BJ
2型糖尿病（T2DM）是一种在全球范围内迅速增加的慢性疾病，已被公认为各种癌症的重要风险因素。尽管许多因素影响T2DM和癌症的发展，包括性别、年龄、种族、肥胖、饮食、体力活动水平和环境暴露，但许多流行病学和实验研究正在逐步促进关于DM和癌症之间相互关系的知识。胰岛素抵抗、高胰岛素血症和与糖尿病相关的慢性炎症都与癌症密切相关。在糖尿病中发生的生物可利用的卵巢类固醇激素的变化（雌激素和雄激素水平升高以及孕酮水平降低）也被认为是女性乳腺、子宫内膜和卵巢的潜在致癌性疾病。此外，胰岛素、胰岛素样生长因子（IGFs）和卵巢类固醇激素（如雌激素和孕酮）之间的相互作用可能在癌症发展过程中协同作用。在这里，我们回顾了T2DM的癌症相关机制，T2DM和女性癌症的流行病学证据，以及抗糖尿病药物在这些癌症中的作用。
Type 2 diabetes mellitus (T2DM), a chronic disease increasing rapidly worldwide, is well established as an important risk factor for various types of cancer. Although many factors impact the development of T2DM and cancer including sex, age, ethnicity, obesity, diet, physical activity levels, and environmental exposure, many epidemiological and experimental studies are gradually contributing to knowledge regarding the interrelationship between DM and cancer. The insulin resistance, hyperinsulinemia, and chronic inflammation associated with diabetes mellitus are all associated strongly with cancer. The changes in bioavailable ovarian steroid hormone that occur in diabetes mellitus (the increasing levels of estrogen and androgen and the decreasing level of progesterone) are also considered potentially carcinogenic conditions for the breast, endometrium, and ovaries in women. In addition, the interaction among insulin, insulin-like growth factors (IGFs), and ovarian steroid hormones, such as estrogen and progesterone, could act synergistically during cancer development. Here, we review the cancer-related mechanisms in T2DM, the epidemiological evidence linking T2DM and cancers in women, and the role of antidiabetic medication in these cancers.
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DOI：
10.1073/pnas.0403621101
发表时间：
2004-07-06
影响因子：
11.1
作者：
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