Alcohol use as a risk factor for tuberculosis - a systematic review.
Alcohol use as a risk factor for tuberculosis - a systematic review.
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DOI：
10.1186/1471-2458-8-289
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发表时间：
2008-08-14
影响因子：
4.5
通讯作者：
Dye, Christopher
中科院分区：
文献类型：
--
作者：
Loennroth, Knut;Williams, Brian G.;Stadlin, Stephanie;Jaramillo, Ernesto;Dye, Christopher
长期以来，饮酒与结核病风险之间存在着明显的关联。目前尚不清楚这种关联在多大程度上受到与饮酒相关的社会因素和其他因素的影响。该协会的实力也尚未确定。本研究的目的是系统地回顾关于饮酒与结核病风险之间关联的现有证据。基于系统文献综述，我们确定了 3 项队列研究和 18 项病例对照研究。根据暴露的定义、用作研究结果的结核病类型以及控制的混杂因素对这些进行了进一步分类。获得每个研究子类别的汇总效应大小。所有将暴露截止水平设定为每天 40 克酒精或以上，或将暴露定义为酒精使用障碍临床诊断的研究的汇总相对风险为 3.50（95% CI：2.01-5.93）。排除小型研究后，由于疑似发表偏倚，汇总相对风险为 2.94（95% CI：1.89-4.59）。控制了各种混杂因素的研究的亚组分析没有给出显着不同的结果，也没有解释研究中发现的显着异质性。每天饮酒超过 40 克酒精和/或患有酒精使用障碍的人患活动性结核病的风险显着升高。这可能是由于与饮酒相关的特定社会混合模式相关的感染风险增加，以及酒精本身和酒精相关病症对免疫系统的影响。
It has long been evident that there is an association between alcohol use and risk of tuberculosis. It has not been established to what extent this association is confounded by social and other factors related to alcohol use. Nor has the strength of the association been established. The objective of this study was to systematically review the available evidence on the association between alcohol use and the risk of tuberculosis. Based on a systematic literature review, we identified 3 cohort and 18 case control studies. These were further categorized according to definition of exposure, type of tuberculosis used as study outcome, and confounders controlled for. Pooled effect sizes were obtained for each sub-category of studies. The pooled relative risk across all studies that used an exposure cut-off level set at 40 g alcohol per day or above, or defined exposure as a clinical diagnosis of an alcohol use disorder, was 3.50 (95% CI: 2.01–5.93). After exclusion of small studies, because of suspected publication bias, the pooled relative risk was 2.94 (95% CI: 1.89–4.59). Subgroup analyses of studies that had controlled for various sets of confounders did not give significantly different results and did not explain the significant heterogeneity that was found across the studies. The risk of active tuberculosis is substantially elevated in people who drink more than 40 g alcohol per day, and/or have an alcohol use disorder. This may be due to both increased risk of infection related to specific social mixing patterns associated with alcohol use, as well as influence on the immune system of alcohol itself and of alcohol related conditions.
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DOI：
10.1111/j.1530-0277.1995.tb01521.x
发表时间：
1995-04-01
影响因子：
3.2
作者：
GREENBERG, S;XIE, JM;MASON, C
通讯作者：
MASON, C
影响因子：
3.1
作者：
Mason, CM;Dobard, E;Nelson, S
通讯作者：
Nelson, S
影响因子：
3.8
作者：
Bobrik, A;Danishevski, K;McKee, M
通讯作者：
McKee, M
影响因子：
5
作者：
ENARSON, DA;WANG, JS;DIRKS, JM
通讯作者：
DIRKS, JM
DOI：
10.1001/jama.1954.03690320026008
发表时间：
1954-01-01
影响因子：
120.7
作者：
JONES, HW;BRANTNER, J
通讯作者：
BRANTNER, J