Natural binocular depth discrimination behavior in mice explained by visual cortical activity.
Natural binocular depth discrimination behavior in mice explained by visual cortical activity.
复制标题
DOI：
10.1016/j.cub.2021.02.031
复制
发表时间：
2021-05-24
期刊：
影响因子：
--
通讯作者：
McGee AW
中科院分区：
文献类型：
--
作者：
Boone HC;Samonds JM;Crouse EC;Barr C;Priebe NJ;McGee AW
在小鼠和其他哺乳动物中，前脑神经元整合右眼和左眼信息以生成视觉环境的三维表示。小鼠视觉皮层中的神经元对双眼视差敏感，但尚不清楚这种敏感性是否与深度感知有关。我们基于经典的视觉悬崖和极点下降任务开发了一个自然任务来估计小鼠深度辨别的心理物理范围。当周围的远（深）表面逐渐变远时，具有双眼视觉的小鼠更频繁地下降到近（浅）表面。一只眼睛的遮挡严重损害了他们瞄准近表面的能力。我们量化了动物做出决定的距离，以估计近和远表面上棋盘图案的双目图像位移。然后，我们使用双光子显微镜分析了初级视觉皮层 (V1) 中大量双眼神经元的视差敏感性，并将 V1 中可用的信息与其行为敏感性进行定量比较。 V1 中的视差信息与所检查深度范围内的行为表现相匹配，并且不受双眼对准变化的影响。这些发现表明，小鼠自然地使用立体线索来指导其行为，并表明了这种深度辨别任务的神经基础。布恩等人。估计具有改良悬崖任务的小鼠的深度辨别的心理物理范围。他们证明小鼠需要双眼视觉来执行任务，并确定来自视觉皮层神经元群体的差异信息足以预测一定深度范围内的表现。
In mice and other mammals, forebrain neurons integrate right and left eye information to generate a three-dimensional representation of the visual environment. Neurons in the visual cortex of mice are sensitive to binocular disparity, yet it is unclear whether that sensitivity is linked to the perception of depth. We developed a natural task based on the classic visual cliff and pole descent tasks to estimate the psychophysical range of mouse depth discrimination. Mice with binocular vision descended to a near (shallow) surface more often when surrounding far (deep) surfaces were progressively more distant. Occlusion of one eye severely impaired their ability to target the near surface. We quantified the distance at which animals make their decisions to estimate the binocular image displacement of the checkerboard pattern on the near and far surfaces. Then we assayed the disparity sensitivity of large populations of binocular neurons in primary visual cortex (V1) using two-photon microscopy, and quantitatively compared this information available in V1 to their behavioral sensitivity. Disparity information in V1 matches the behavioral performance over the range of depths examined and was resistant to changes in binocular alignment. These findings reveal that mice naturally use stereoscopic cues to guide their behavior and indicate a neural basis for this depth discrimination task. Boone et al. estimate the psychophysical range of depth discrimination for mice with a modified cliff task. They demonstrate mice require binocular vision to perform the task and identify that disparity information from populations of neurons in visual cortex is sufficient to predict performance across a range of depths.
登录
查看更多内容
影响因子：
16.6
作者：
Mazziotti R;Baroncelli L;Ceglia N;Chelini G;Sala GD;Magnan C;Napoli D;Putignano E;Silingardi D;Tola J;Tognini P;Arthur JSC;Baldi P;Pizzorusso T
通讯作者：
Pizzorusso T
影响因子：
25
作者：
Mathis, Alexander;Mamidanna, Pranav;Bethge, Matthias
通讯作者：
Bethge, Matthias
影响因子：
5.3
作者：
Haverkamp, S;Wässle, H;Euler, T
通讯作者：
Euler, T
影响因子：
0.6
作者：
DEWSBURY, DA;LANIER, DL;MIGLIETTA, A
通讯作者：
MIGLIETTA, A
影响因子：
--
作者：
Meister M;Cox D
通讯作者：
Cox D