Sub-topographic maps for regionally enhanced analysis of visual space in the mouse retina.
Sub-topographic maps for regionally enhanced analysis of visual space in the mouse retina.
复制标题
小鼠视网膜中视觉空间的区域增强分析的子图形图。
DOI：
10.1002/cne.24457
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Huberman AD
中科院分区：
文献类型：
--
作者：
El-Danaf RN;Huberman AD
在许多物种中，神经元在视网膜上的分布是不均匀的，导致在视觉空间的某些位置对特定视觉特征的分析不均匀。近年来，小鼠已成为探索视觉系统功能，发育和疾病的首选模型。因此，实现鼠标视觉电路架构的详细了解是至关重要的。一般认为，小鼠具有相对均匀的视网膜神经节细胞（RGC）-眼睛的输出神经元-的地形分布。然而，小鼠RGC包括约30个亚型;每个亚型对视觉场景中的特定特征反应最好，并将该信息传达给中心目标。鉴于RGC的关键作用和小鼠作为模型的突出性，我们询问了不同的RGC亚型如何分布在视网膜上。我们从整个视网膜表面靶向并填充单个荧光标记的RGC亚型，并根据其特定的视网膜位置评估每个细胞的树突状乔木范围和索马大小。三种主要的RGC亚型：开-关方向选择性RGCs，对象运动敏感的RGCs，和一个专门的子类的非图像形成的RGCs各自有显着的地形变化，在他们的树突乔木的大小。此外，每个RGC亚型的变异模式是不同的。因此，有越来越多的证据表明，小鼠视网膜编码视觉空间在特定区域的方式。因此，某些视觉特征在某些视网膜位置处的采样比其他位置更密集。这些发现对这种突出的模式物种的中央视觉处理，感知和行为具有影响。所有的视觉信息都是通过视网膜神经节细胞（RGC）的各种亚型的活动来处理的。作为研究视觉系统的重要模型，小鼠视网膜被认为以统一的方式编码视觉空间。在这里，我们发现，三种形态和功能不同的RGCs亚型显示出不同的视网膜组织。因此，位于视觉空间不同部分的信号在大脑中被不同地传达和分析。
In many species, neurons are unevenly distributed across the retina, leading to nonuniform analysis of specific visual features at certain locations in visual space. In recent years, the mouse has emerged as a premiere model for probing visual system function, development and disease. Thus, achieving a detailed understanding of mouse visual circuit architecture is of paramount importance. The general belief is that mice possess a relatively even topographic distribution of retinal ganglion cells (RGCs)- the output neurons of the eye. However, mouse RGCs include ~30 subtypes; each responds best to a specific feature in the visual scene and conveys that information to central targets. Given the crucial role of RGCs and the prominence of the mouse as a model, we asked how different RGC subtypes are distributed across the retina. We targeted and filled individual fluorescently tagged RGC subtypes from across the retinal surface and evaluated the dendritic arbor extent and soma size of each cell according to its specific retinotopic position. Three prominent RGC subtypes: On-Off direction selective RGCs, object-motion-sensitive RGCs, and a specialized subclass of non-image-forming RGCs each had marked topographic variations in their dendritic arbor sizes. Moreover, the pattern of variation was distinct for each RGC subtype. Thus, there is increasing evidence that the mouse retina encodes visual space in a region-specific manner. As a consequence, some visual features are sampled far more densely at certain retinal locations than others. These findings have implications for central visual processing, perception and behavior in this prominent model species. All visual information is processed through the activity of various subtypes of retinal ganglion cells (RGCs). As a prominent model for studying the visual system, the mouse retina was thought to encode visual space in a uniform manner. Here, we discovered that three morphologically and functionally distinct subtypes of RGCs show distinct retinotopic organizations. Therefore, signals located in different portions of the visual space are conveyed and analyzed differently in the brain.
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视网膜神经节细胞变性是拓扑的，但在DBA/2J小鼠中不是特异性细胞类型。
影响因子：
7.8
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
9.2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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