Comprehensive molecular characterization of hypertension-related genes in cancer.
Comprehensive molecular characterization of hypertension-related genes in cancer.
复制标题
DOI：
10.1186/s40959-022-00136-z
复制
发表时间：
2022-05-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
在癌症治疗期间，患者发生心血管并发症（如高血压）的风险显著增加。在这项研究中，我们调查了高血压与不同类型癌症之间的内在关系。首先，我们全面描述了33种癌症中10种高血压相关基因的参与情况。对每种类型的癌症鉴定每个基因的体细胞拷贝数改变（CNA）和单核苷酸变异（SNV）。然后，分析了14种癌症中高血压相关基因的表达模式。高血压相关基因在不同类型的癌症中表达异常，有些与患者的总生存期或癌症分期有关。随后，通过分析高血压相关基因和临床可操作基因（CAG）之间的共表达和蛋白质-蛋白质相互作用来确定它们之间的相互作用。我们发现某些高血压相关基因与CAG相关。接下来，与高血压相关基因相关的通路被确定。正相关的通路包括上皮细胞向间质细胞转化、激素雄激素受体和受体酪氨酸激酶，负相关的通路包括凋亡、细胞周期和DNA损伤反应。最后，针对不同药物和不同类型的癌症，评估高血压相关基因与药物敏感性之间的相关性。高血压相关基因均与肿瘤对大多数抗癌药物的耐药性呈正或负相关。这些结果突出了高血压相关基因在癌症中的重要性。本研究为后基因组时代高血压相关基因与癌症的关系提供了一种新的研究方法。在线版本包含补充材料，可通过10.1186/s40959-022-00136-z获得。
During cancer treatment, patients have a significantly higher risk of developing cardiovascular complications such as hypertension. In this study, we investigated the internal relationships between hypertension and different types of cancer. First, we comprehensively characterized the involvement of 10 hypertension-related genes across 33 types of cancer. The somatic copy number alteration (CNA) and single nucleotide variant (SNV) of each gene were identified for each type of cancer. Then, the expression patterns of hypertension-related genes were analyzed across 14 types of cancer. The hypertension-related genes were aberrantly expressed in different types of cancer, and some were associated with the overall survival of patients or the cancer stage. Subsequently, the interactions between hypertension-related genes and clinically actionable genes (CAGs) were identified by analyzing the co-expressions and protein–protein interactions. We found that certain hypertension-related genes were correlated with CAGs. Next, the pathways associated with hypertension-related genes were identified. The positively correlated pathways included epithelial to mesenchymal transition, hormone androgen receptor, and receptor tyrosine kinase, and the negatively correlated pathways included apoptosis, cell cycle, and DNA damage response. Finally, the correlations between hypertension-related genes and drug sensitivity were evaluated for different drugs and different types of cancer. The hypertension-related genes were all positively or negatively correlated with the resistance of cancer to the majority of anti-cancer drugs. These results highlight the importance of hypertension-related genes in cancer. This study provides an approach to characterize the relationship between hypertension-related genes and cancers in the post-genomic era. The online version contains supplementary material available at 10.1186/s40959-022-00136-z.
DOI：
10.1007/s10552-010-9590-x
发表时间：
2010-10
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Largent JA;Bernstein L;Horn-Ross PL;Marshall SF;Neuhausen S;Reynolds P;Ursin G;Zell JA;Ziogas A;Anton-Culver H
通讯作者：
Anton-Culver H