Hypertension, antihypertensive medication use, and breast cancer risk in the California Teachers Study cohort.
Hypertension, antihypertensive medication use, and breast cancer risk in the California Teachers Study cohort.
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DOI：
10.1007/s10552-010-9590-x
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Anton-Culver H
中科院分区：
文献类型：
--
作者：
Largent JA;Bernstein L;Horn-Ross PL;Marshall SF;Neuhausen S;Reynolds P;Ursin G;Zell JA;Ziogas A;Anton-Culver H
我们在一项大型前瞻性研究--加州教师研究（CTS）中调查了高血压、抗高血压（AH）药物使用和乳腺癌之间的关系。1995-1996年，从114 549名妇女中收集了高血压史和终生定期使用AH药物的信息。其中，1995年至2006年期间诊断出4 151例浸润性乳腺癌。2000-2001年从73 742名妇女那里收集了关于AH使用的补充信息，其中1 714名妇女后来被诊断患有乳腺癌。考克斯比例风险回归用于估计乳腺癌的相对危险度（RR）和95%置信区间（CI）。与未使用AH药物相比，使用AH药物≥5年与浸润性乳腺癌风险适度增加相关（RR = 1.18，95%CI 1.02-1.36）。这种增加的风险似乎仅限于雌激素受体（ER）阳性肿瘤（RR = 1.21，95%CI 1.03-1.43）和绝经前/围绝经期妇女（RR = 1.58，95%CI 1.11-2.25）。观察到长期（≥5年）AH使用的浸润性乳腺癌风险增加，这似乎仅限于ER +乳腺癌和年轻女性。
We investigated the association between hypertension, antihypertensive (AH) medication use, and breast cancer in a large prospective study, the California Teachers Study (CTS). Information on history of hypertension and lifetime regular use of AH medications was collected from 114,549 women in 1995–1996. Among them, 4,151 invasive breast cancers were diagnosed between 1995 and 2006. Additional information on AH use was collected from 73,742 women in 2000–2001, and 1,714 of these women were subsequently diagnosed with breast cancer. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) for breast cancer. Use of AH medication for ≥5 years, when compared with no use, was associated with a modest increased risk of invasive breast cancer (RR = 1.18, 95%CI 1.02–1.36). This increased risk appeared to be confined to estrogen receptor (ER)-positive tumors (RR = 1.21, 95%CI 1.03–1.43) and pre-/peri-menopausal women (RR = 1.58, 95%CI 1.11–2.25). Increased risk of invasive breast cancer was observed for long-term (≥5 years) AH use, and this appeared to be confined to ER + breast cancer and younger women.
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DOI：
10.1158/1055-9965.epi-09-0235
发表时间：
2009-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kabat GC;Kim M;Chlebowski RT;Khandekar J;Ko MG;McTiernan A;Neuhouser ML;Parker DR;Shikany JM;Stefanick ML;Thomson CA;Rohan TE
通讯作者：
Rohan TE
影响因子：
8.3
作者：
HAMET, P;RICHARD, L;TREMBLAY, J
通讯作者：
TREMBLAY, J
影响因子：
6.4
作者：
Lindgren, Annamarja;Pukkala, Eero;Nissinen, Aulikki
通讯作者：
Nissinen, Aulikki
影响因子：
5.6
作者：
Hunt, Kelly J.;Lukanova, Annekatrin;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf
影响因子：
4.9
作者：
Peeters, PHM;van Noord, PAH;Grobbee, DE
通讯作者：
Grobbee, DE