Excitability of the motor cortex in patients with migraine changes with the time elapsed from the last attack.
Excitability of the motor cortex in patients with migraine changes with the time elapsed from the last attack.
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DOI：
10.1186/s10194-016-0712-z
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Pierelli F
中科院分区：
文献类型：
--
作者：
Cortese F;Coppola G;Di Lenola D;Serrao M;Di Lorenzo C;Parisi V;Pierelli F
运动皮层单脉冲经颅磁刺激（TMS）产生的运动诱发电位（MEPs）是衡量皮层兴奋性的客观指标。以前，偏头痛患者的MEP阈值是正常的，升高的，甚至降低的。在本研究中，我们确定了皮层兴奋性水平是否随最后一次偏头痛发作的时间间隔而变化，从而解释了先前报道的不一致性。26例未经治疗的无先兆偏头痛（MO）患者在两次发作之间进行了MEP研究。然后将他们的数据与从24名健康志愿者（HVs）那里收集的MEP数据进行比较。在实验中，经颅磁刺激8字线圈被放置在左侧运动区域。在确定静息运动阈值（RMT）后，我们传递了10个单次TMS脉冲（频率：0.1 Hz，强度：RMT的120%），并平均得到MEP振幅。MO组和HV组的平均RMTs和MEP振幅无显著差异。在MO患者中，rmt与上次偏头痛发作后的天数呈负相关（rho = -0.404, p = 0.04）。我们的研究结果表明，唤醒mep的阈值受到攻击的接近程度的影响；具体来说，当攻击发生后一段很长的时间间隔后，阈值较低，当接近攻击时，阈值较高（在正常值范围内）。这些动态RMT变化类似于我们之前报道的视觉和体感诱发电位，可能代表了与偏头痛周期相关的大脑兴奋性的时间依赖性可塑性变化。
Motor-evoked potentials (MEPs) produced by single-pulse transcranial magnetic stimulation (TMS) of the motor cortex can be an objective measure of cortical excitability. Previously, MEP thresholds were found to be normal, increased, or even reduced in patients with migraine. In the present study, we determined whether the level of cortical excitability changes with the time interval from the last migraine attack, thereby accounting for the inconsistencies in previous reports. Twenty-six patients with untreated migraine without aura (MO) underwent a MEP study between attacks. Their data were then compared to the MEP data collected from a group of 24 healthy volunteers (HVs). During the experiment, the TMS figure-of-eight coil was positioned over the left motor area. After identifying the resting motor threshold (RMT), we delivered 10 single TMS pulses (rate: 0.1 Hz, intensity: 120% of the RMT) and averaged the resulting MEP amplitudes. The mean RMTs and MEP amplitudes were not significantly different between the MO and HV groups. In patients with MO, the RMTs were negatively correlated with the number of days elapsed since the last migraine attack (rho = -0.404, p = 0.04). Our results suggest that the threshold for evoking MEPs is influenced by the proximity of an attack; specifically, the threshold is lower when a long time interval has passed after an attack, and is higher (within the range of normative values) when measured close to an attack. These dynamic RMT variations resemble those we reported previously for visual and somatosensory evoked potentials and may represent time-dependent plastic changes in brain excitability in relation to the migraine cycle.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
影响因子：
5
作者：
BETTUCCI, D;CANTELLO, R;MUTANI, R
通讯作者：
MUTANI, R
影响因子：
4.9
作者：
Shepherd, Alex J.;Wyatt, Geddes;Tibber, Marc S.
通讯作者：
Tibber, Marc S.
DOI：
10.1186/1129-2377-14-76
发表时间：
2013-09-09
期刊：
The journal of headache and pain
影响因子：
--
作者：
Coppola G;Iacovelli E;Bracaglia M;Serrao M;Di Lorenzo C;Pierelli F
通讯作者：
Pierelli F
DOI：
10.1016/j.clinph.2012.01.010
发表时间：
2012-05
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Groppa S;Oliviero A;Eisen A;Quartarone A;Cohen LG;Mall V;Kaelin-Lang A;Mima T;Rossi S;Thickbroom GW;Rossini PM;Ziemann U;Valls-Solé J;Siebner HR
通讯作者：
Siebner HR