The relationship of adverse childhood experiences to a history of premature death of family members.
The relationship of adverse childhood experiences to a history of premature death of family members.
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DOI：
10.1186/1471-2458-9-106
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发表时间：
2009-04-16
影响因子：
4.5
通讯作者：
Dube SR
中科院分区：
文献类型：
--
作者：
Anda RF;Dong M;Brown DW;Felitti VJ;Giles WH;Perry GS;Valerie EJ;Dube SR
评估不良童年经历 (ACE)（包括童年虐待和忽视）与严重的家庭功能失调以及家庭成员过早死亡之间的关联。由于 ACE 会增加成人许多主要死亡原因的风险，并且往往是家族性和代际性的，因此我们假设，报告有更多 ACE 的人更有可能有家庭成员面临过早死亡的风险。我们使用了 17,337 名成人健康计划成员的数据，他们完成了一项关于 10 种 ACE 以及家庭成员是否在 65 岁之前死亡的调查。评估了家庭成员过早死亡的发生率及其与 ACE 的关系。与没有经历过任何类型 ACE 的受访者家庭成员相比，经历过任何类型 ACE 的受访者家庭成员过早死亡的患病率更有可能升高 (p < 0.01)。最高风险发生在那些自称在童年时期受到身体忽视、与药物滥用或犯罪家庭成员生活在一起的人。在所有年龄组中都观察到家庭中 ACE 数量与过早死亡之间存在强大的分级关系，并且报告 0 ACE 和 ≥ 4 ACE 的组之间的比较得出 OR 为 1.8（95% CI，1.6-2.0）。不良的童年经历可能表明家庭环境混乱，导致家庭成员过早死亡的风险增加。
To assess the association between adverse childhood experiences (ACEs), including childhood abuse and neglect, and serious household dysfunction, and premature death of a family member. Because ACEs increase the risk for many of the leading causes of death in adults and tend to be familial and intergenerational, we hypothesized that persons who report having more ACEs would be more likely to have family members at risk of premature death. We used data from 17,337 adult health plan members who completed a survey about 10 types of ACEs and whether a family member died before age 65. The prevalence of family member premature death and its association with ACEs were assessed. Family members of respondents who experienced any type of ACEs were more likely to have elevated prevalence for premature death relative to those of respondents without such experience (p < 0.01). The highest risk occurred among those who reported having been physically neglected and living with substance abusing or criminal family members during childhood. A powerful graded relationship between the number of ACEs and premature mortality in the family was observed for all age groups, and comparison between groups reporting 0 ACE and ≥ 4 ACEs yielded an OR of 1.8 (95%CI, 1.6–2.0). Adverse childhood experiences may be an indicator of a chaotic family environment that results in an increased risk of premature death among family members.
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通讯作者：
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通讯作者：
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