Association of gout with brain reserve and vulnerability to neurodegenerative disease.
Association of gout with brain reserve and vulnerability to neurodegenerative disease.
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DOI：
10.1038/s41467-023-38602-6
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发表时间：
2023-05-18
影响因子：
16.6
通讯作者：
Nichols, Thomas E.
中科院分区：
文献类型：
--
作者：
Topiwala, Anya;Mankia, Kulveer;Bell, Steven;Webb, Alastair;Ebmeier, Klaus P.;Howard, Isobel;Wang, Chaoyue;Alfaro-Almagro, Fidel;Miller, Karla;Burgess, Stephen;Smith, Stephen;Nichols, Thomas E.
痛风中神经退行性疾病风险的研究是矛盾的。与大脑结构的神经成像标记物的关系，这可能提供见解，是不确定的。在这里，我们调查了痛风，脑结构和神经退行性疾病发病率之间的关系。通过观察和遗传学方法，痛风患者的全球和区域脑体积较小，脑铁标记物较高。痛风患者的全因痴呆、帕金森病和可能的原发性震颤的发病率也较高。风险具有强烈的时间依赖性，其中与痴呆事件的关联在痛风诊断后的前3年最高。这些发现表明痛风与大脑结构的几个指标有因果关系。痛风患者的脑储备较低可能解释了他们对多种神经退行性疾病的易感性。运动和认知障碍可能会影响痛风患者，特别是在诊断后的最初几年。神经退行性疾病风险与痛风之间的潜在联系尚未完全了解。在这里，作者表明，痛风与大脑结构的几个指标有因果关系，这可能解释了他们更容易患痴呆症。
Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson’s disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis. The potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia.
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影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
27.4
作者：
Latourte, Augustin;Soumare, Aicha;Richette, Pascal
通讯作者：
Richette, Pascal
影响因子：
11
作者：
Ayton, Scott;Wang, Yamin;Bush, Ashley I.
通讯作者：
Bush, Ashley I.
影响因子：
2.5
作者：
Lee, Young Ho
通讯作者：
Lee, Young Ho