Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population.
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population.
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DOI：
10.1093/aje/kwx246
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发表时间：
2017-11-01
影响因子：
5
通讯作者：
Allen NE
中科院分区：
文献类型：
--
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
英国生物银行队列是一个以人口为基础的队列，在2006年至2010年期间在英国招募了50万参与者。在英格兰、威尔士和苏格兰的22个评估中心中，约有920万居住在25英里（40公里）范围内的40 - 69岁的人被邀请进入队列，5.5%的人参加了基线评估。通过比较无应答者和应答者之间的人口学特征来调查英国生物银行队列的代表性。将该队列的社会人口学、体质、生活方式和健康相关特征与全国代表性数据源进行比较。与非参与者相比，英国生物银行的参与者更有可能是老年人、女性，并且生活在社会经济贫困程度较低的地区。与一般人群相比，参与者不太可能肥胖、吸烟和每天饮酒，也很少有自我报告的健康状况。在70-74岁年龄段，男性的全因死亡率和总癌症发病率分别比同年龄人群低46.2%和11.8%，女性的全因死亡率和总癌症发病率分别比同年龄人群低55.5%和18.1%。UK Biobank不能代表抽样人群；有证据表明存在“健康志愿者”的选择偏见。尽管如此，对暴露与疾病关系的有效评估可能具有广泛的普遍性，并且不要求参与者在整个人群中具有代表性。
The UK Biobank cohort is a population-based cohort of 500,000 participants recruited in the United Kingdom (UK) between 2006 and 2010. Approximately 9.2 million individuals aged 40–69 years who lived within 25 miles (40 km) of one of 22 assessment centers in England, Wales, and Scotland were invited to enter the cohort, and 5.5% participated in the baseline assessment. The representativeness of the UK Biobank cohort was investigated by comparing demographic characteristics between nonresponders and responders. Sociodemographic, physical, lifestyle, and health-related characteristics of the cohort were compared with nationally representative data sources. UK Biobank participants were more likely to be older, to be female, and to live in less socioeconomically deprived areas than nonparticipants. Compared with the general population, participants were less likely to be obese, to smoke, and to drink alcohol on a daily basis and had fewer self-reported health conditions. At age 70–74 years, rates of all-cause mortality and total cancer incidence were 46.2% and 11.8% lower, respectively, in men and 55.5% and 18.1% lower, respectively, in women than in the general population of the same age. UK Biobank is not representative of the sampling population; there is evidence of a “healthy volunteer” selection bias. Nonetheless, valid assessment of exposure-disease relationships may be widely generalizable and does not require participants to be representative of the population at large.
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影响因子：
2.5
作者：
Burnell, Matthew;Gentry-Maharaj, Aleksandra;Menon, Usha
通讯作者：
Menon, Usha
影响因子：
6.3
作者：
Andreeva, Valentina A.;Salanave, Benoit;Hercberg, Serge
通讯作者：
Hercberg, Serge
影响因子：
7.4
作者：
Mishra, Gita Devi;Hockey, Richard;Dobson, Annette
通讯作者：
Dobson, Annette
影响因子：
5
作者：
Manolio TA;Weis BK;Cowie CC;Hoover RN;Hudson K;Kramer BS;Berg C;Collins R;Ewart W;Gaziano JM;Hirschfeld S;Marcus PM;Masys D;McCarty CA;McLaughlin J;Patel AV;Peakman T;Pedersen NL;Schaefer C;Scott JA;Sprosen T;Walport M;Collins FS
通讯作者：
Collins FS
影响因子：
5.4
作者：
Hernán, MA;Hernández-Díaz, S;Robins, JM
通讯作者：
Robins, JM