Adenoma Prevalence and Distribution Among US Latino Subgroups Undergoing Screening Colonoscopy.
Adenoma Prevalence and Distribution Among US Latino Subgroups Undergoing Screening Colonoscopy.
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DOI：
10.1007/s10620-016-4381-1
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发表时间：
2017-06
影响因子：
3.1
通讯作者：
Itzkowitz SH
中科院分区：
文献类型：
--
作者：
Chablani SV;Jandorf L;DuHamel K;Lee KK;Sriphanlop P;Villagra C;Itzkowitz SH
结直肠癌 (CRC) 是美国拉丁裔中诊断出的第二大恶性肿瘤。美国的拉丁裔代表了遗传背景、文化和社会经济地位各异的亚群体的异质混合体。对于拉丁裔亚群中筛查结肠镜检查时发现的 CRC 前体病变的频率知之甚少。目的是根据亚组和社会人口背景，确定平均风险、无症状的美国拉丁美洲人在结肠镜检查中发现的经组织学证实的腺瘤的患病率和分布。在学术医疗中心进行的两项前瞻性随机对照试验中，对年龄 ≥ 50 岁的平均风险、无症状的美国拉丁裔人群进行结肠镜筛查所得到的病理结果进行横断面分析。在完成结肠镜检查的 561 名拉丁美洲人中，最大的两个亚组是波多黎各人和多米尼加人。两个亚组的结果分别为：腺瘤 30.6%，近端腺瘤 23.5%，晚期腺瘤 12.0%，近端晚期腺瘤 8.9%。这些比率至少与美国白人结肠镜检查中发现的比率一样高。虽然波多黎各人比多米尼加人更有可能出生在美国、说英语、文化适应、有吸烟史和肥胖，但这些亚组之间的腺瘤发生率没有显着差异。两个亚组中腺瘤、晚期腺瘤和近端肿瘤的患病率均较高。这些发现对美国日益增长的拉丁裔人口中的结直肠癌筛查和监测具有重要意义。
Colorectal cancer (CRC) is the second leading malignancy diagnosed among U.S. Latinos. Latinos in the U.S. represent a heterogeneous amalgam of subgroups varying in genetic background, culture, and socioeconomic status. Little is known about the frequency of CRC precursor lesions found at screening colonoscopy among Latino subgroups. The aim was to determine the prevalence and distribution of histologically-confirmed adenomas found at screening colonoscopy among average-risk, asymptomatic U.S. Latinos according to their subgroup and socio-demographic background. Cross-sectional analysis of pathological findings resulting from screening colonoscopy among average-risk, asymptomatic U.S. Latinos aged ≥ 50 in two prospective randomized controlled trials at an academic medical center. Among the 561 Latinos who completed screening colonoscopy, the two largest subgroups were Puerto Ricans and Dominicans. The findings among both subgroups were: adenomas 30.6%, proximal adenomas 23.5%, advanced adenomas 12.0%, and proximal advanced adenomas 8.9%. These rates are at least as high as those found at screening colonoscopy among U.S. whites. While Puerto Ricans were more likely than Dominicans to be born in the U.S., speak English, be acculturated, have a smoking history, and be obese, there were no significant differences in adenoma rates between these subgroups. The prevalence of adenomas, advanced adenomas, and proximal neoplasia was high among both subgroups. These findings have implications for CRC screening and surveillance among the increasingly growing Latino population in the U.S.
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影响因子：
1.9
作者：
Braschi, Caitlyn D.;Sly, Jamilia R.;Jandorf, Lina
通讯作者：
Jandorf, Lina
影响因子：
5.5
作者：
Bustamante, Arturo Vargas;Chen, Jie;Ortega, Alexander N.
通讯作者：
Ortega, Alexander N.
影响因子：
39.2
作者：
Imperiale, TF;Wagner, DR;Ransohoff, DF
通讯作者：
Ransohoff, DF
DOI：
10.1590/s1020-49892009000500003
发表时间：
2009-05-01
期刊：
Revista Panamericana de Salud Pública
影响因子：
--
作者：
Ho, Gloria Y. F.;Figueroa-Vallés, Nayda R.;Rohan, Thomas E.
通讯作者：
Rohan, Thomas E.
影响因子：
3.4
作者：
Collazo, Tyson H.;Jandorf, Lina;Itzkowitz, Steven H.
通讯作者：
Itzkowitz, Steven H.