Psoriasis: a mixed autoimmune and autoinflammatory disease.
Psoriasis: a mixed autoimmune and autoinflammatory disease.
复制标题
DOI：
10.1016/j.coi.2017.07.007
复制
发表时间：
2017-12
影响因子：
7
通讯作者：
Gudjonsson JE
中科院分区：
文献类型：
--
作者：
Liang Y;Sarkar MK;Tsoi LC;Gudjonsson JE
近年来，我们对银屑病的关键生物学和免疫学途径的理解取得了显著进展。遗传学研究表明，银屑病的易感性涉及适应性和先天免疫系统的组成部分，并且在银屑病皮肤中发现免疫系统的这两个分支的激活并不令人惊讶。虽然适应性免疫反应在慢性斑块状银屑病中占主导地位，但先天性和自身炎症反应在脓疱型银屑病中占主导地位，其他临床亚型在斑块和脓疱型银屑病之间延伸。这使得银屑病成为一种独特的疾病，其中自身免疫和自身炎症反应共存，两者之间的平衡对于形成其临床表现至关重要。概览图。免疫学上银屑病的特征在于自身免疫和自身炎性免疫反应的混合。两者之间的平衡决定了银屑病的临床表现，其中慢性斑块状银屑病具有突出的适应性/自身免疫反应，而脓疱型银屑病则以自身炎症免疫反应为主。现有的证据表明，银屑病的其他临床亚型存在于这两种临床表型之间的光谱上。
In recent years marked progress has been made in our understanding of the critical biologic and immunologic pathways involved in psoriasis. Genetic studies have demonstrated that susceptibility to psoriasis involves components of both the adaptive and innate immune system and not surprisingly activation of both of these arms of the immune system is found in psoriatic skin. While adaptive immune responses predominate in chronic plaque psoriasis, innate and autoinflammatory responses dominate in pustular forms of psoriasis, with other clinical subtypes extending on a spectrum between plaque and pustular psoriasis. This makes psoriasis a unique disease where both autoimmune and autoinflammatory responses co-exist, with the balance between the two being critical in shaping its clinical presentation. Overview figure. Immunologically psoriasis is characterized by a mixture of both autoimmune and autoinflammatory immune responses. The balance between the two dictate the clinical presentation of psoriasis with chronic plaque psoriasis having prominent adaptive / autoimmune responses while pustular psoriasis is dominated by autoinflammatory immune responses. Available evidence indicates that other clinical subtypes of psoriasis exist on a spectrum between these two clinical phenotypes.
登录
查看更多内容
影响因子：
82.9
作者：
Conrad, Curdin;Boyman, Onur;Nestle, Frank O.
通讯作者：
Nestle, Frank O.
DOI：
10.4049/jimmunol.1301481
发表时间：
2014-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Foster AM;Baliwag J;Chen CS;Guzman AM;Stoll SW;Gudjonsson JE;Ward NL;Johnston A
通讯作者：
Johnston A
DOI：
10.4049/jimmunol.1003162
发表时间：
2011-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Johnston A;Xing X;Guzman AM;Riblett M;Loyd CM;Ward NL;Wohn C;Prens EP;Wang F;Maier LE;Kang S;Voorhees JJ;Elder JT;Gudjonsson JE
通讯作者：
Gudjonsson JE
影响因子：
6.5
作者：
Lin, WJ;Norris, DA;Tomkinson, B
通讯作者：
Tomkinson, B
影响因子：
9.8
作者：
Jordan, Catherine T.;Cao, Li;Bowcock, Anne M.
通讯作者：
Bowcock, Anne M.