IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.
IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.
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DOI：
10.4049/jimmunol.1301481
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发表时间：
2014-06-15
期刊：
影响因子：
--
通讯作者：
Johnston A
中科院分区：
文献类型：
--
作者：
Foster AM;Baliwag J;Chen CS;Guzman AM;Stoll SW;Gudjonsson JE;Ward NL;Johnston A
IL-1家族成员IL-36α（IL-1F 6）、IL-36β（IL-1F 8）和IL-36γ（IL-1F 9）以及受体拮抗剂IL-36 Ra（IL-1F 5）构成了一种新的信号传导系统，但目前对其了解甚少。我们现在表明，这些细胞因子对皮肤免疫系统有深远的影响。用IL-36细胞因子处理人角质形成细胞显著增加了CXCL 1、CXCL 8、CCL 3、CCL 5和CCL 20（活化白细胞的强效趋化剂）的表达，皮内注射IL-36α导致小鼠皮肤的趋化因子表达、白细胞浸润和棘皮症。血液单核细胞、髓样树突状细胞（DC）和单核细胞衍生的DC（MO-DC）表达IL-36 R并对IL-36产生应答。相反，IL-36对静息或活化的人CD 4+或CD 8 + T细胞或血液嗜中性粒细胞没有直接作用。单核细胞表达IL-1A、IL-1B和IL-6 mRNA，IL-1β和IL-6蛋白，mDC上调CD 83、CD 86和HLADR的表面表达以及IL-1β和IL-6的分泌。此外，IL-36α处理的MO-DC促进同种异体CD 4 + T细胞增殖，表明IL-36可以刺激DC的成熟和功能，并驱动T细胞增殖。这些数据表明，IL-36细胞因子通过激活角质形成细胞、抗原呈递细胞和间接激活T细胞而积极传播皮肤炎症。
The IL-1 family members IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) and the receptor antagonist IL-36Ra (IL-1F5) constitute a novel signaling system that is poorly understood. We now show that these cytokines have profound effects on the skin immune system. Treatment of human keratinocytes with IL-36 cytokines significantly increased the expression of CXCL1, CXCL8, CCL3, CCL5, and CCL20, potent chemotactic agents for activated leukocytes, and IL-36α injected intradermally resulted in chemokine expression, leukocyte infiltration and acanthosis of mouse skin. Blood monocytes, myeloid dendritic cells (DC) and monocyte-derived DC (MO-DC) expressed IL-36R and responded to IL-36. In contrast, no direct effects of IL-36 on resting or activated human CD4+ or CD8+ T cells, or blood neutrophils, could be demonstrated. Monocytes expressed IL-1A, IL-1B and IL-6 mRNA and IL-1β and IL-6 protein and mDC upregulated surface expression of CD83, CD86 and HLADR and secretion of IL-1β and IL-6 after treatment with IL-36. Furthermore, IL-36α-treated MO-DC enhanced allogeneic CD4+ T cell proliferation, demonstrating that IL-36 can stimulate the maturation and function of DC and drive T cell proliferation. These data indicate that IL-36 cytokines actively propagate skin inflammation via the activation of keratinocytes, antigen presenting cells and, indirectly, T cells.
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DOI：
10.4049/jimmunol.181.7.4733
发表时间：
2008-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kryczek I;Bruce AT;Gudjonsson JE;Johnston A;Aphale A;Vatan L;Szeliga W;Wang Y;Liu Y;Welling TH;Elder JT;Zou W
通讯作者：
Zou W
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影响因子：
15.3
作者：
Cosmi, Lorenzo;De Palma, Raffaele;Santarlasci, Veronica;Maggi, Laura;Capone, Manuela;Frosali, Francesca;Rodolico, Gabriella;Querci, Valentina;Abbate, Gianfranco;Angeli, Roberta;Berrino, Liberato;Fambrini, Massimiliano;Caproni, Marzia;Tonelli, Francesco;Lazzeri, Elena;Parronchi, Paola;Liotta, Francesco;Maggi, Enrico;Romagnani, Sergio;Annunziato, Francesco
通讯作者：
Annunziato, Francesco
影响因子：
6.5
作者：
Kennedy-Crispin, Milene;Billick, Erika;Mitsui, Hiroshi;Gulati, Nicholas;Fujita, Hideki;Gilleaudeau, Patricia;Sullivan-Whalen, Mary;Johnson-Huang, Leanne M.;Suarez-Farinas, Mayte;Krueger, James G.
通讯作者：
Krueger, James G.
DOI：
10.4049/jimmunol.1003162
发表时间：
2011-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Johnston A;Xing X;Guzman AM;Riblett M;Loyd CM;Ward NL;Wohn C;Prens EP;Wang F;Maier LE;Kang S;Voorhees JJ;Elder JT;Gudjonsson JE
通讯作者：
Gudjonsson JE
影响因子：
4.6
作者：
Johnston, A;Gudjonsson, JE;Valdimarsson, H
通讯作者：
Valdimarsson, H