Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces
Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces
复制标题
锌取代纳米羟基磷灰石涂层对种植体表面骨整合的影响
DOI：
10.1631/jzus.b1200327
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Yang, Guo-li
中科院分区：
文献类型：
--
作者：
Zhao, Shi-fang;Dong, Wen-jing;Jiang, Qiao-hong;He, Fu-ming;Wang, Xiao-xiang;Yang, Guo-li
目的本研究的目的是通过电化学过程研究锌取代纳米羟基磷灰石（Zn-HA）涂层对兔模型种植体骨整合的影响。方法采用电化学过程沉积Zn-HA涂层或HA涂层。使用场发射扫描电子显微镜检查表面形态。使用X射线衍射仪（XRD）和傅里叶变换红外光谱（FTIR）检查了涂层的晶体结构和化学成分。总共 78 个植入物被植入兔子的股骨和胫骨中。两周、四周和八周后，取回股骨和胫骨并准备进行组织形态学评估和移除扭矩（RTQ）测试。结果两个植入物表面均出现棒状HA晶体。 Zn-HA 晶体的尺寸似乎比 HA 的尺寸小。 XRD 图案显示两种涂层的峰与标准 HA 图案匹配良好。 FTIR 光谱显示两种涂层均由 HA 晶体组成。 Zn-HA 涂层显着改善了四周和八周后所有螺纹内的骨面积（P<0.05）、四周后的骨与种植体接触（BIC）（P<0.05）以及四周和八周后的 RTQ 值（P<0.05）。结论该研究表明电化学沉积的 Zn-HA 涂层具有改善骨与种植体表面整合的潜力。
ObjectiveThe purpose of this study was to investigate the effects of a zinc-substituted nano-hydroxyapatite (Zn-HA) coating, applied by an electrochemical process, on implant osseointegraton in a rabbit model.MethodsA Zn-HA coating or an HA coating was deposited using an electrochemical process. Surface morphology was examined using field-emission scanning electron microscopy. The crystal structure and chemical composition of the coatings were examined using an X-ray diffractometer (XRD) and Fourier transform infrared spectroscopy (FTIR). A total of 78 implants were inserted into femurs and tibias of rabbits. After two, four, and eight weeks, femurs and tibias were retrieved and prepared for histomorphometric evaluation and removal torque (RTQ) tests.ResultsRod-like HA crystals appeared on both implant surfaces. The dimensions of the Zn-HA crystals seemed to be smaller than those of HA. XRD patterns showed that the peaks of both coatings matched well with standard HA patterns. FTIR spectra showed that both coatings consisted of HA crystals. The Zn-HA coating significantly improved the bone area within all threads after four and eight weeks (P<0.05), the bone to implant contact (BIC) at four weeks (P<0.05), and RTQ values after four and eight weeks (P<0.05).ConclusionsThe study showed that an electrochemically deposited Zn-HA coating has potential for improving bone integration with an implant surface.
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DOI：
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发表时间：
1988-07
期刊：
Bone and mineral
影响因子：
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作者：
Angus Rm;P. Sambrook;N. Pocock;J. Eisman
通讯作者：
Angus Rm;P. Sambrook;N. Pocock;J. Eisman
影响因子：
14
作者：
ELLIES, LG;NELSON, DGA;FEATHERSTONE, JDB
通讯作者：
FEATHERSTONE, JDB
影响因子：
5
作者：
E. Kaufmann
通讯作者：
E. Kaufmann
DOI：
10.1002/jbm.a.32055
发表时间：
2009-06
期刊：
Journal of biomedical materials research. Part A
影响因子：
--
作者：
Guo-li Yang;F. He;Xiao-feng Yang;Xiao-xiang Wang;Shi-fang Zhao
通讯作者：
Guo-li Yang;F. He;Xiao-feng Yang;Xiao-xiang Wang;Shi-fang Zhao
DOI：
--
发表时间：
1998
期刊：
The International journal of prosthodontics
影响因子：
--
作者：
J. Davies
通讯作者：
J. Davies