Hepatitis C transmission in a hemodialysis unit: Molecular evidence for spread of virus among patients not sharing equipment
Hepatitis C transmission in a hemodialysis unit: Molecular evidence for spread of virus among patients not sharing equipment
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血液透析室中的丙型肝炎传播：病毒在不共用设备的患者中传播的分子证据
DOI：
10.1002/jmv.1890430417
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发表时间：
1994
影响因子：
12.7
通讯作者：
M. Persson
中科院分区：
文献类型：
--
作者：
T. Allander;C. Medin;S. Jacobson;L. Grillner;M. Persson
三例同时血清转化为丙型肝炎病毒（HCV）在血液透析单位启动了调查的病毒株的14个血清阳性患者在该单位的核苷酸测序。结果显示，五名患者感染了相同的病毒株，并表明另外两名患者感染了第二种病毒株。传播与输血无关，与透析机无关，但发生在同一班次接受治疗的患者之间。病例数高于血清学数据的预期。因此，尽管采取了严格的预防措施，但在可通过胃肠外途径传播的环境中，病毒传播仍可能以高频率发生。这可能会引起人们的担忧，即非输血相关的HCV传播可能存在，并且在几家医院中未被注意到。© 1994 Wiley利斯公司
Three cases of simultaneous seroconversion to hepatitis C virus (HCV) in a hemodialysis unit initiated the investigation of the viral strains of 14 seropositive patients in the unit by nucleotide sequencing. The results showed that five patients had been infected with the same viral strain, and indicated that two other patients were sharing a second strain. Transmission was not related to blood transfusions and not associated with the dialysis machines, but occurred between patients treated on the same shift. The number of cases was higher than expected from the serological data. Thus, spread of virus may occur at high frequencies in environments where parenteral routes are made accessible, in spite of rigorous preventive measures. This may raise concern that non‐transfusion associated spread of HCV may be present and unnoticed in several hospital settings. © 1994 Wiley‐Liss, Inc.
DOI：
10.1073/pnas.88.24.11236
发表时间：
1991-12-01
影响因子：
11.1
作者：
BURGER, H;WEISER, B;GIBBS, RA
通讯作者：
GIBBS, RA