TRIM family proteins and their emerging roles in innate immunity.
TRIM family proteins and their emerging roles in innate immunity.
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DOI：
10.1038/nri2413
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Morse HC 3rd
中科院分区：
文献类型：
--
作者：
Ozato K;Shin DM;Chang TH;Morse HC 3rd
含有三个基序的超家族(TRIM)在后生动物王国中是保守的，并在脊椎动物进化过程中迅速扩大；目前在人类和小鼠中已知的TRIM蛋白有60多种。许多TRIM蛋白是由I型和II型干扰素诱导的，这对抵抗病原体的许多方面都是至关重要的，其中一些已知是限制慢病毒感染所必需的。在这篇综述中，我们描述了最近的数据，揭示了TRIM蛋白更广泛的抗病毒和抗微生物活性，并讨论了它们参与调节病原体识别和宿主防御的转录途径。
The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now more than 60 TRIM proteins known in humans and mice. Many TRIM proteins are induced by type I and type II interferons, which are crucial for many aspects of resistance to pathogens, and several are known to be required for the restriction of infection by lentiviruses. In this Review, we describe recent data that reveal broader antiviral and antimicrobial activities of TRIM proteins and discuss their involvement in the regulation of pathogen-recognition and transcriptional pathways in host defence.
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