Age-Related Increase in Mortality among Patients with First Myocardial Infarctions Treated with Thrombolysis
Age-Related Increase in Mortality among Patients with First Myocardial Infarctions Treated with Thrombolysis
复制标题
接受溶栓治疗的首次心肌梗塞患者的死亡率与年龄相关
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
G. Tognoni
中科院分区：
文献类型：
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作者：
A. Maggioni;A. Maseri;C. Fresco;M. Franzosi;F. Mauri;E. Santoro;G. Tognoni
背景：众所周知，缺血性心脏病的总死亡率随着年龄的增长而逐渐增加。我们评估了首次心肌梗死溶栓治疗患者的死亡率与年龄之间的关系。方法我们研究了9720例首次梗死的患者，这些患者已被纳入吉西-2试验。(This试验比较了心肌梗死患者中组织型纤溶酶原激活剂与链激酶的疗效。）其中，只有35%的人有心绞痛病史。年龄与住院期间和出院后6个月内死亡率之间的关系通过未校正和校正分析确定。结果40岁以下患者的住院死亡率为1.9%，而80岁以上患者的住院死亡率则上升至31.9%;然而，梗死面积指标的值并不随年龄而增加。在医院死亡的772名患者中，有20%进行了尸检。
Background The overall rate of mortality due to ischemic heart disease is known to increase progressively with age. We evaluated the relation between the mortality rate and age in patients with first myocardial infarctions treated with thrombolytic therapy. Methods We studied 9720 patients with first infarctions who had been enrolled in the GISSI-2 trial. (This trial compared the efficacy of tissue plasminogen activator with that of streptokinase in patients with myocardial infarction.) Of these, only 35 percent had a history of angina. The relation between age and mortality during hospitalization and during the six months after discharge was determined by unadjusted and adjusted analyses. Results The in-hospital mortality rate was 1.9 percent among patients 40 years old or younger, but it increased to 31.9 percent among those more than 80 years old; however, values for indicators of infarct size did not increase with age. Autopsies were performed in 20 percent of the 772 patients who died in the hospital...
影响因子：
20.1
作者：
OLIVETTI, G;MELISSARI, M;ANVERSA, P
通讯作者：
ANVERSA, P