The Emerging Role of Glucose Metabolism in Cartilage Development.
The Emerging Role of Glucose Metabolism in Cartilage Development.
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DOI：
10.1007/s11914-019-00506-0
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发表时间：
2019-04
影响因子：
4.3
通讯作者：
Zeng L
中科院分区：
文献类型：
--
作者：
Hollander JM;Zeng L
软骨内骨化过程中，软骨的正常发育是骨形成的关键。本文就软骨发育过程中软骨细胞葡萄糖代谢的各个方面的研究现状作一综述。最近的研究表明，软骨细胞在软骨内成骨过程中可以转分化为成骨细胞和骨髓基质细胞。在软骨发育中，信号分子，包括IGF2和BMP2，以阶段特异性的方式严格控制葡萄糖的吸收和利用。糖代谢的紊乱改变了软骨细胞的成熟过程，提示糖代谢在软骨内成骨过程中起着关键作用。在出生前和出生后的生长过程中，软骨细胞经历了营养供应和能量消耗的激增，这需要对软骨基质产生、细胞增殖和肥大等依赖葡萄糖的过程进行复杂的控制。因此，研究糖代谢的调节可能导致软骨发育中信号事件的统一机制，并有助于深入了解骨骼生长异常的原因。
Proper cartilage development is critical to bone formation during endochondral ossification. This review highlights the current understanding of various aspects of glucose metabolism in chondrocytes during cartilage development. Recent studies indicate that chondrocytes transdifferentiate into osteoblasts and bone marrow stromal cells during endochondral ossification. In cartilage development, signaling molecules, including IGF2 and BMP2, tightly control glucose uptake and utilization in a stage-specific manner. Perturbation of glucose metabolism alters the course of chondrocyte maturation, suggesting a key role for glucose metabolism during endochondral ossification. During prenatal and postnatal growth, chondrocytes experience bursts of nutrient availability and energy expenditure, which demand sophisticated control of the glucose-dependent processes of cartilage matrix production, cell proliferation, and hypertrophy. Investigating the regulation of glucose metabolism may therefore lead to a unifying mechanism for signaling events in cartilage development and provide insight into causes of skeletal growth abnormalities.
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