Salmonella infection: Interplay between the bacteria and host immune system.

Salmonella infection: Interplay between the bacteria and host immune system.
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DOI:
10.1016/j.imlet.2017.07.006
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发表时间:
2017-10
期刊:
影响因子:
4.4
通讯作者:
McLachlan JB
McLachlan JB
中科院分区:
医学3区
文献类型:
--
作者:
Kurtz JR;Goggins JA;McLachlan JB

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沙门氏菌感染导致世界各地的发病率和死亡率,宿主的免疫反应取决于感染是急性和局限性的还是全身性的和慢性的。此外,沙门氏菌为了自身的利益已经进化出多种机制来避免或破坏免疫,而且感染的解剖位置往往在免疫反应和细菌命运中都起着作用。在这里,我们概述了免疫系统和沙门氏菌之间的相互作用,同时讨论了不同的宿主和细菌因素如何影响感染的结果。
Salmonella infection causes morbidity and mortality throughout the world with the host immune response varying depending on whether the infection is acute and limited, or systemic and chronic. Additionally, Salmonella bacteria have evolved multiple mechanisms to avoid or subvert immunity to its own benefit and often the anatomical location of infection plays a role in both the immune response and bacterial fate. Here, we provide an overview of the interplay between the immune system and Salmonella, while discussing how different host and bacterial factors influence the outcome of infection.
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