Powering the cell cycle

Powering the cell cycle
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为细胞周期提供动力

DOI:
10.1126/science.aaa2313
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发表时间:
2014
期刊:
影响因子:
56.9
通讯作者:
Rehling P.
Rehling P.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Schulz C.;Rehling P.

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生活意味着成长、回应、繁殖和适应。所有这些过程都需要能量,在大多数真核细胞中,能量是由线粒体氧化磷酸化提供的。此外,线粒体还参与其他重要的细胞过程,包括程序性细胞死亡(凋亡)和钙信号传导。因此,线粒体功能必须紧密地整合到细胞环境中,而参与这种协调的机制才刚刚开始被理解。在本期的第1109页,Harbaueret等人确定了细胞分裂周期和线粒体蛋白质转运之间的联系,作为这一过程的驱动因素。
To live means to grow, respond, reproduce, and adapt. All these processes require energy, which in most eukaryotic cells is provided by mitochondrial oxidative phosphorylation. Moreover, mitochondria have been implicated in other vital cellular processes, including programmed cell death (apoptosis) and calcium signaling. Hence, mitochondrial functions have to be tightly integrated into the cellular context, and the mechanisms that participate in this coordination are only just beginning to be understood. On page 1109 of this issue, Harbaueret al.identify a link between the cell division cycle and mitochondrial protein transport as a driver of this process.
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